Endotypes of allergic diseases and asthma: An important step in building blocks for the future of precision medicine

Article in Press

Ioana Agache

,

 Cezmi A. Akdis

Open Access

DOI: http://dx.doi.org/10.1016/j.alit.2016.04.011

Article Info

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Abstract

Discoveries from basic science research in the last decade have brought significant progress in knowledge of pathophysiologic processes of allergic diseases, with a compelling impact on understanding of the natural history, risk prediction, treatment selection or mechanism-specific prevention strategies. The view of the pathophysiology of allergic diseases developed from a mechanistic approach, with a focus on symptoms and organ function, to the recognition of a complex network of immunological pathways. Several subtypes of inflammation and complex immune-regulatory networks and the reasons for their failure are now described, that open the way for the development of new diagnostic tools and innovative targeted-treatments.

MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis

Articles in Press

Jean Bousquet, MD, Holger J. Schünemann, MD, Peter W. Hellings, MD, Sylvie Arnavielhe, PhD, Claus Bachert, MD, Anna Bedbrook, BSc, Karl-Christian Bergmann, MD, Sinthia Bosnic-Anticevich, PhD, Jan Brozek, MD, Moises Calderon, MD, G. Walter Canonica, MD, Thomas B. Casale, MD, Niels H. Chavannes, MD, Linda Cox, MD, Henry Chrystyn, PhD, Alvaro A. Cruz, MD, Ronald Dahl, MD, Giuseppe De Carlo, MD, Pascal Demoly, MD, Phillipe Devillier, MD, Gérard Dray, PhD, Monica Fletcher, MSc, Wytske J. Fokkens, MD, Joao Fonseca, MD, Sandra N. Gonzalez-Diaz, MD, Lawrence Grouse, MD, Thomas Keil, MD, Piotr Kuna, MD, Désirée Larenas-Linnemann, MD, Karin C. Lodrup Carlsen, MD, Eli O. Meltzer, MD, Jaoquim Mullol, MD, Antonella Muraro, MD, Robert N. Naclerio, MD, Susanna Palkonen, MD, Nikolaos G. Papadopoulos, MD, Giovanni Passalacqua, MD, David Price, MD, Dermot Ryan, MD, Boleslaw Samolinski, MD, Glenis K. Scadding, MD, Aziz Sheikh, MD, Arunas Valiulis, MD, Erkka Valovirta, MD, Samantha Walker, PhD, Magnus Wickman, MD, Arzu Yorgancioglu, MD, Torsten Zuberbier, MD on behalf of the show MASK study group*

Open Access DOI: http://dx.doi.org/10.1016/j.jaci.2016.03.025

Article Info

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The selection of pharmacotherapy for patients with allergic rhinitis (AR) depends on several factors, including age, prominent symptoms, symptom severity, control of AR, patient preferences, and cost. Allergen exposure and the resulting symptoms vary, and treatment adjustment is required. Clinical decision support systems (CDSSs) might be beneficial for the assessment of disease control. CDSSs should be based on the best evidence and algorithms to aid patients and health care professionals to jointly determine treatment and its step-up or step-down strategy depending on AR control.

Relation of the Timing of Onset of Rhinitis and Cough to Asthma Attack in Children

The Kurume Medical Journal

Article ID: MS65011

 http://doi.org/10.2739/kurumemedj.MS65011

TETSU SUGIMURA¹⁾, YUKIKO OZAKI²⁾, YOSHIFUMI TANANARI³⁾, RUMI YAMAKAWA²⁾, RUMIKO HIRATA²⁾

1) Department of Pediatrics and Allergology, Sugimura Children’s Medical Clinic 2) Department of Pediatrics, Kurume University School of Medicine 3) Department of Pediatrics, Wada Children’s Clinic

[Advance Publication] Released 20160525

Summary: If the risk of progression to asthma could be predicted in patients with rhinitis, prevention of asthma might become possible. The purpose of this study was to clarify the relationship between the duration of rhinitis symptoms and acute asthma attacks in children with a history of asthma who were not on treatment for asthma. In 94 children with a history of asthma who were asymptomatic after completing asthma treatment, we investigated the onset and duration of nasal discharge and cough related to allergic rhinitis.

Maternal serum but not breast milk IL-5, IL-6, and IL-13 immune markers are associated with scratching among infants

RESEARCH

 

OPEN ACCESS

• Nelís Soto-Ramírez,
• Keith Boyd,
• Hongmei Zhang,
• Venugopal Gangur,
• Laura Goetzl and
• Wilfried KarmausEmail author

Allergy, Asthma & Clinical Immunology201612:25

DOI: 10.1186/s13223-016-0129-x

Abstract

Background

Scratching in infants is considered to be related to early development of eczema. Little is known about the effects of maternal immune markers on scratching among infants. The objective is to compare the risks related to maternal serum immune markers (IMs) during pregnancy and IMs in breast milk for the occurrence of scratching in infants at 6 and 12 months of age.

Interactive digital interventions to promote self-management in adults with asthma: systematic review and meta-analysis

RESEARCH ARTICLE

 

OPEN ACCESS

 

OPEN PEER REVIEW

• Gary McLeanEmail author,
• Elizabeth Murray,
• Rebecca Band,
• Keith R. Moffat,
• Peter Hanlon,
• Anne Bruton,
• Mike Thomas,
• Lucy Yardley and
• Frances S. Mair

BMC Pulmonary MedicineBMC series – open, inclusive and trusted201616:83

DOI: 10.1186/s12890-016-0248-7

Open Peer Review reports

Abstract

Background

To identify, summarise and synthesise the evidence for using interactive digital interventions to support patient self-management of asthma, and determine their impact.

Methods

Systematic review with meta-analysis. We searched MEDLINE, EMBASE, CINAHL, PsycINFO, ERIC, Cochrane Library, DoPHER, TROPHI, Social Science Citation Index and Science Citation Index. The selection criteria requirement was studies of adults (16 years and over) with asthma, interventions that were interactive digital interventions and the comparator was usual care.

Allergen inhalation challenge, refractoriness and the effects of ibuprofen

RESEARCH

 

OPEN ACCESS

• Shawn Nomani,
• Donald W. Cockcroft and
• Beth E. DavisEmail author

Allergy, Asthma & Clinical Immunology201612:24

DOI: 10.1186/s13223-016-0127-z

Abstract

Background

Bronchoprovocation challenges use direct or indirect acting stimuli to induce airflow obstruction. Indirect stimuli either non-allergic/non-IgE mediated (e.g. exercise, mannitol) or allergic/IgE mediated (i.e. allergen) trigger mast cells to release bronchoconstricting mediators (e.g. cysteinyl leukotrienes, histamine). Performing repeat challenges within a short timeframe (e.g. 3 h) with non-allergic indirect stimuli results in a diminished, refractory response to the second challenge that is inhibited by non-steroidal anti-inflammatory medications. Cross refractoriness occurs between indirect stimuli.

LINX®, a novel treatment for patients with refractory asthma complicated by gastroesophageal reflux disease: a case report

CASE REPORT

 

OPEN ACCESS

• Narin SriratanaviriyakulEmail author,
• Celeste Kivler,
• Tamas J. Vidovszky,
• Ken Y. Yoneda,
• Nicholas J. Kenyon,
• Susan Murin and
• Samuel Louie

Journal of Medical Case Reports201610:124

DOI: 10.1186/s13256-016-0887-6

Open Peer Review reports

Abstract

Background

Gastroesophageal reflux disease is one of the most common comorbidities in patients with asthma. Gastroesophageal reflux disease can be linked to difficult-to-control asthma. Current management includes gastric acid suppression therapy and surgical antireflux procedures. The LINX® procedure is a novel surgical treatment for patients with gastroesophageal reflux disease refractory to medical therapy.

Financial Relationships between Organizations That Produce Clinical Practice Guidelines and the Biomedical Industry: A Cross-Sectional Study

• Paul Campsall,
• Kate Colizza,
• Sharon Straus,
• Henry T. Stelfox

http://dx.doi.org/10.1371/journal.pmed.1002029

Abstract

Background

Financial relationships between organizations that produce clinical practice guidelines and biomedical companies are vulnerable to conflicts of interest. We sought to determine whether organizations that produce clinical practice guidelines have financial relationships with biomedical companies and whether there are associations between organizations’ conflict of interest policies and recommendations and disclosures provided in guidelines.

Microbiome and its Impact on Gastrointestinal Atopy

Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

DOI: 10.1111/all.12943

Amanda B. Muir^1,2,*, 

Alain J. Benitez³,

Kara Dods¹, 

Jonathan M. Spergel^2,3and

Sophie A. Fillon⁴

• Abstract

Abstract

The prevalence of allergic conditions has continuously increased in the last few decades in Westernized countries. A dysbiotic gut microbiome may play an important role in the development of allergic diseases. Genetic, environmental and dietary factors may alter the commensal microbiota leading to inflammatory dysregulation of homeostasis. Murine and human studies have begun to elucidate the role of the microbiota in the pathogenesis of atopic diseases including asthma, atopic dermatitis and food allergies. However, the role of the microbiome in most eosinophilic gastrointestinal diseases (EGIDs) is not yet known. This review provides an overview of what is currently known about the development of tolerance from both molecular and clinical standpoints. We also look at the gut specific microbiome and its role in atopic conditions with the hope of applying this knowledge to the understanding, prevention and treatment of EGIDs, particularly EoE.

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Periostin - A Novel Systemic Biomarker for Eosinophilic Airway Inflammation: A Case Control Study

•  Clin Diagn Res
• v.10(2); 2016 Feb
• PMC4800558

J Clin Diagn Res. 2016 Feb; 10(2): OC01–OC04.

Published online 2016 Feb 1. doi:  10.7860/JCDR/2016/14553.7166

PMCID: PMC4800558

Viswanathan Emprm,1 MG Rajanandh,2 and AD Nageswari3

Author information ► Article notes ► Copyright and License information ►

Abstract

Introduction

Chronic airway inflammation and remodelling are fundamental features of asthma. The molecular phenotypes in asthma are Th2 high and Th2 low. Serum periostin is a biomarker which aid in understanding Th2 high eosinophilic asthma.

Aim

The present study aimed to identify whether or not serum periostin is a systemic biomarker for eosinophilic airway inflammation in asthmatics.

Updosing of nonsedating anti-histamines in recalcitrant chronic urticaria

REVIEW ARTICLE

Year : 2016  |  Volume : 61  |  Issue : 3  |  Page : 273-278

Kiran Godse, Prachi Bhattar, Sharmila Patil, Nitin Nadkarni, Manjyot GautamDepartment of Dermatology, Dr. D. Y. Patil Medical College and Hospital, Nerul, Navi Mumbai, Maharashtra, India Abstract   Chronic urticaria (CU) is a persistent, debilitating condition that causes severe impairment on the quality of life (QoL) of patient by interrupting work productivity. Current guidelines recommend second-generation (nonsedating) anti-histamines for the treatment for all forms of urticaria. In patients who do not respond adequately to conventional doses of anti-histamines, it is recommended to increase the dose to up to four times to obtain control. But there are only few controlled studies that have assessed the efficacy and safety of nonsedating anti-histamines.

Occupational and environmental risk factors for chronic rhinosinusitis in China: a multicentre cross-sectional study

Respiratory Research201617:54

DOI: 10.1186/s12931-016-0366-z

Wen-Xiang Gao, Chun-Quan Ou, Shu-Bin Fang, Yue-Qi Sun, Hua Zhang, Lei Cheng, Yan-Jun Wang, Dong-Dong Zhu, Wei Lv, Shi-Xi Liu, P. Z. Li, Geng Xu, Jianbo Shi and Qing-Ling Fu

Background

Chronic rhinosinusitis (CRS) is defined as a condition of inflammation in the paranasal sinus mucosa persisting for more than 12 weeks. We previously reported that the prevalence of CRS was about 8 % in China. Here, we aim to investigate the occupational and environmental risk factors associated with CRS.

How relevant is panallergen sensitisation in the development of allergies?

Pediatric Allergy and Immunology

Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

• Abstract
• Cited By

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Abstract

Panallergens comprise various protein families of plant as well as animal origin and are responsible for wide IgE cross-reactivity between related and unrelated allergenic sources.