Gut microbiota relationships to lung function and adult asthma phenotype: a pilot study

BMJ Open Respiratory Research 2018;5:e000324. doi: 10.1136/bmjresp-2018-000324

Lesa Begley1,  Siddharth Madapoosi1,  Kristopher Opron1,2,  Ogechukwu Ndum3,  Alan Baptist3,  Kelly Rysso1,  John R Erb-Downward1 and  Yvonne Jean Huang1
Abstract
Introduction Despite strong evidence that maturation patterns of the gut microbiome in early life influence the risk for childhood asthma, very little is known about gut microbiota patterns in adults with established asthma, and of greater interest relationships to phenotypic features that characterise asthma heterogeneity.

Seafood allergy: A comprehensive review of fish and shellfish allergens

Molecular Immunology

Volume 100, August 2018, Pages 28-57

Author links open overlay panelThimoRuethersabcd1Aya C.Takiabcd1Elecia B.JohnstonacdRoniNugrahaacdeThu T.K.LeacdTanjaKalicfThomas R.McLeangSandip D.KamathabcdAndreas L.Lopataabcd

https://doi.org/10.1016/j.molimm.2018.04.008

Highlights

•

Immunological cross-reactivity between fish and shellfish allergens has not been demonstrated conclusively.

A comparative analysis of errors in inhaler technique among COPD versus asthma patients

 International Journal of Chronic Obstructive Pulmonary Disease Volume 2018:13 Pages 2941—2947

Birsen Ocakli,¹ Ipek Ozmen,¹ Eylem Acartürk Tunçay,¹ Sinem Gungor,¹ Hilal Altinoz,¹ Nalan Adiguzel,¹Zafer Ali Sak,² Gokay Gungor,¹ Zuhal Karakurt,¹ Peri Arbak<sup>3

1</sup>University of Health Sciences, Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey; ²Department of Chest Diseases, Harran University, Faculty of Medicine, Sanliurfa, Turkey; ³Department of Chest Diseases, Duzce University, Faculty of Medicine, Duzce, Turkey

Purpose: This study was designed to evaluate errors in inhaler technique in COPD vs asthma patients and to investigate the association of poor inhaler technique with patient demographics and clinical variables.

An observational cohort study of the use of five-grass-pollen extract sublingual immunotherapy during the 2015 pollen season in France

• Research
• Open Access

• Patrick BlinEmail authorView ORCID ID profile,
• Pascal Demoly,
• Martine Drouet,
• Bruno Falissard,
• Séverine Lignot-Maleyran,
• Hélène Maizi,
• Simon Lorrain,
• Régis Lassalle,
• Cécile Droz-Perroteau,
• Nicholas Moore and
• Mathieu Molimard

Allergy, Asthma & Clinical Immunology201814:38

Abstract

Background

Allergic rhinitis affects around one quarter of the Western European population. Prophylactic allergen immunotherapy may be useful to reduce the risk of acute symptomatic attacks (hayfever). A five-grass pollen extract sublingual immunotherapy (5GPE-SLIT) has been developed for the treatment of allergic rhinitis to grass pollen.

Duration of Allergen Immunotherapy for Long-Term Efficacy in Allergic Rhinoconjunctivitis

Current Treatment Options in Allergy

September 2018, Volume 5, Issue 3, pp 275–290

• Martin Penagos 
• Aarif O. Eifan 
• Stephen R. Durham
• Guy W. Scadding

1. 1.

Open Access 

Specific Immunotherapy (L Cox, Section Editor)

First Online: 31 August 2018

Part of the following topical collections:

1. Topical Collection on Specific Immunotherapy

Abstract

Rationale

Subcutaneous and sublingual immunotherapy are effective for allergic rhinitis. An important question is whether allergen immunotherapy provides a sustained clinical effect after treatment cessation. In view of potential side effects, cost and the necessary patient commitment, long-term benefit is an important consideration for the recommendation of immunotherapy over standard pharmacotherapy.

The following new articles have just been published in Allergy, Asthma & Clinical Immunology

Allergy, Asthma & Clinical Immunology

The following new articles have just been published in Allergy, Asthma & Clinical Immunology REVIEW Anaphylaxis David Fischer, Timothy K. Vander Leek, Anne K. Ellis and Harold Kim Allergy, Asthma & Clinical Immunology 2018, 14:54 | Published on: 12 September 2018 Full Text | PDF

Common allergies in urban adolescents and their relationships with asthma control and healthcare utilization

• Research Open Access

• Hyekyun Rhee

• ,
• Tanzy Love,
• Donald Harrington and
• Annette Grape

Allergy, Asthma & Clinical Immunology201814:33

Urban adolescents suffer a disproportionate burden of asthma morbidity, often in association with allergies. Literature is limited on comparing various types of allergies regarding prevalence and associations with asthma morbidity in urban dwelling adolescents. The purpose of this study was to examine the prevalence of common allergies reported by urban adolescents and to assess their relationships to healthcare utilization and asthma control.

Association Between Use of Acid-Suppressive Medications and Antibiotics During Infancy and Allergic Diseases in Early Childhood

Edward Mitre, MD1; Apryl Susi, MS2; Laura E. Kropp, MPH1; et alDavid J. Schwartz, MD3; Gregory H. Gorman, MD2; Cade M. Nylund, MD2

JAMA Pediatr. 2018;172(6):e180315. doi:10.1001/jamapediatrics.2018.0315

Key Points

Question Does use of medications that disturb the microbiome in infancy increase subsequent risk of developing allergic diseases?

Findings In this cohort study of 792 130 children, the hazard of developing an allergic disease was significantly increased in those who had received acid-suppressive medications or antibiotics during the first 6 months of life.

Conjunctivitis occurring in atopic dermatitis patients treated with dupilumab–clinical characteristics and treatment

September–October, 2018Volume 6, Issue 5, Pages 1778–1780.e1

Andreas Wollenberg, MD, PhDCorrespondence information about the author MD, PhD Andreas WollenbergEmail the author MD, PhD Andreas Wollenberg

, 

Lieneke Ariens, MD

, 

Stephan Thurau, MD, PhD

, 

Chantal van Luijk, MD

, 

Marlene Seegräber, MD

, 

Marjolein de Bruin-Weller, MD, PhD

Open Access

PlumX Metrics

DOI: https://doi.org/10.1016/j.jaip.2018.01.034

 

Article Info

Treatment with the SQ house dust mite sublingual immunotherapy tablet may be initiated year-round

September–October, 2018Volume 6, Issue 5, Pages 1758–1760.e1

Correspondence information about the author MD, PhD Hendrik Nolt

Email the author MD, PhD Hendrik Nolte

Hendrik Nolte, MD, PhD

David I. Bernstein, MD, FAAAAI

, 

Jörg Kleine-Tebbe, MD, FAAAAI

, 

Peter A. Fejerskov, RN, BSN

, 

Qing Li, PhD

, 

Susan Lu, PharmD

, 

Harrold S. Nelson, MD, FAAAAI

Open Access

PlumX Metrics

DOI: https://doi.org/10.1016/j.jaip.2017.12.035

Article Info

Value of a Second Dose of Epinephrine During Anaphylaxis: A Patient/Caregiver Survey

September–October, 2018Volume 6, Issue 5, Pages 1559–1567

T. Ted Song, DOCorrespondence information about the author DO T. Ted SongEmail the author DO T. Ted Song

, 

Duncan Brown, PhD

, 

Martin Karjalainen, MD

, 

Ulrike Lehnigk, PhD

, 

Phil Lieberman, MD

Open Access

PlumX Metrics

DOI: https://doi.org/10.1016/j.jaip.2018.01.019

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Article Info

• Abstract

• Full Text
• Images
• References
• Supplemental Materials

Background

Anaphylaxis guidelines recommend prescription of more than 1 epinephrine autoinjector (EAI) for patients at risk. A second epinephrine dose is required in 16% to 36% of patients.