Allergic multimorbidity is associated with self-reported anaphylaxis in adults—A cross-sectional questionnaire study

Thomander, T, Toppila-Salmi, S, Salimäki, J, et al. Allergic multimorbidity is associated with self-reported anaphylaxis in adults—A cross-sectional questionnaire study. Clin Transl Allergy. 2022;e12184. https://doi.org/10.1002/clt2.12184

Abstract

Background

Anaphylaxis has increased over the last two decades in Europe, reaching an estimated prevalence of 0.3% and an incidence of 1.5–7.9 per 100,000 person-years. Allergic multimorbidity is associated with asthma severity, yet its role in anaphylaxis is not fully understood. Our aim was to study association between allergic multimorbidity and anaphylaxis in adults.

Methods

We used population-based data from the Finnish Allergy Barometer Study (n = 2070, age range: 5–75). Food allergy (FA), atopic dermatitis (AD), allergic rhinitis (AR) and allergic conjunctivitis (AC), were defined from a self-completed questionnaire. A logistic regression adjusted on potential confounders (sex, age, smoking status) was applied to estimate the anaphylaxis risk associated with allergic multimorbidity.

Results

Adjusted odds ratio (OR) and 95%CI of
self-reported anaphylaxis ever are presented for the following
allergic diseases(allergic rhinitis (AR), allergic conjunctivitis (AC),
atopic dermatitis (AD), food allergy (FA), and asthma (AS))
and for the number of allergic diseases. 

1319 adults with at least one allergic disease (FA, AD, AR, AC) with/without asthma (AS) were included. Of these, 164 had self-reported anaphylaxis [mean (SD, min-max) 54 (14, 22–75) years, 17% men]. AS, FA, AR, AC, or AD were reported by 86.0%, 62.2%, 82.3%, 43.3%, and 53.7% of subjects with anaphylaxis and respectively by 67.8%, 29.5%, 86.2%, 29.4%, and 34.4% of subjects without anaphylaxis. Compared with subjects exhibiting only one allergic disease, the risk of anaphylaxis increased with the number of allergic diseases; adjusted odds ratios (OR) [CI95%] for two, three, four and five coinciding allergic diseases were 1.80 [0.79–4.12], 3.35 [1.47–7.66], 7.50 [3.25–17.32], and 13.5 [5.12–33.09], respectively. The highest risk of anaphylaxis (6.47 [4.33–9.92]) was associated with FA + AS or their various variations with AR/AC/AD embodied, when compared with AR, AC, and AS separately or their combinations.

Conclusions

Anaphylaxis was positively associated with the number of allergic diseases a subject exhibited and with subgroups including FA and/or AS. The results can be applied when estimating the risk of anaphylaxis for individual patients.

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Poultry Meat allergy: a Review of Allergens and Clinical Phenotypes

Wanniang, N., Codreanu-Morel, F., Kuehn, A. et al. Poultry Meat allergy: a Review of Allergens and Clinical Phenotypes. Curr Treat Options Allergy 9, 187–203 (2022). https://doi.org/10.1007/s40521-022-00309-2

Abstract

Purpose of review

In the recent years, more cases of poultry meat allergy, both IgE- or non-IgE-mediated, are being reported. Patients have varied clinical reactivity at various levels of sensitivity to different meat preparations. The lack of validated biomarkers renders accurate diagnosis challenging. In this review, we aim to provide an overview of the current status of poultry meat allergy along with a description on the allergens implicated.

Patient-centered dupilumab dosing regimen leads to successful dose reduction in persistently controlled atopic dermatitis

ORIGINAL ARTICLE - Open Access

Lotte S. Spekhorst, Daphne Bakker, Julia Drylewicz, Theo Rispens, Floris Loeff, Celeste M. Boesjes, Judith Thijs, Geertruida L. E. Romeijn, Laura Loman, Marie-Louise Schuttelaar, Femke van Wijk, Marlies de Graaf, Marjolein S. de Bruin-Weller.

Abstract

Background

At present, no real-world studies are available on different dupilumab dosing regimens in controlled atopic dermatitis (AD). The aim of this study was to clinically evaluate a patient-centered dupilumab dosing regimen in patients with controlled AD and to relate this to serum drug levels and serum biomarkers.

Methods

Ninety adult AD patients from the prospective BioDay registry were included based on their dupilumab administration interval according to a predefined patient-centered dosing regimen.

Automatic market research of mobile health apps for the self-management of allergic rhinitis

Antó A, Sousa-Pinto B, Czarlewski W, et al.  

Clin Exp Allergy. 2022 Mar 21. doi: 10.1111/cea.14135.

Abstract

Background

Only a small number of apps addressing allergic rhinitis (AR) patients have been evaluated. This makes their selection difficult. We aimed to introduce a new approach to market research for AR apps, based on the automatic screening of Apple App and Google Play stores.

Methods

A JavaScript programme was devised for automatic app screening, and applied in a market assessment of AR self-management apps. We searched the Google Play and Apple App stores of three countries (USA, UK and Australia) with the following search terms: "hay fever", "hayfever", "asthma", "rhinitis", "allergic rhinitis".

Prevalence of reported food allergies in Brazilian preschoolers living in a small Brazilian city

• Research
• Open Access
• 
  

• José A. da S. Correia, 
• Adriana Azoubel Antunes, 
• Luiz Taborda-Barata, 
• José Laerte Boechat & 
• Emanuel Sávio Cavalcanti Sarinho 

Allergy, Asthma & Clinical Immunology volume 18, Article number: 74 (2022) 

Abstract 

Introduction Although the prevalence of allergic diseases, including food allergies, has increased over recent decades, relevant information on this topic is still lacking, particularly in younger children living in small cities. 

Objective To investigate the prevalence of reported food allergies in preschoolers in Limoeiro/Pernambuco, Brazil.

Methods

This was a cross-sectional study with preschoolers. Parents/guardians of all preschoolers enrolled at municipal schools between March and June 2019 (total of 619) were invited to complete a screening questionnaire (total of 619). Another 151 questionnaires were applied on the streets of the town.

Current treatment strategies for seasonal allergic rhinitis: where are we heading?

Erminia Ridolo, Cristoforo Incorvaia, Francesco Pucciarini, Elena Makri, Giovanni Paoletti & Giorgio Walter Canonica 

Clinical and Molecular Allergy volume 20, Article number: 9 (2022) 

Abstract

Introduction

Allergic rhinitis (AR) is very commonly caused by pollens. The symptoms of AR consist of sneezing, nasal congestion, rhinorrhea, nasal itching and airflow obstruction. The diagnosis has long been based on clinical history, skin prick tests and in vitro measurement of specific IgE, but the innovative approach of precision medicine has made diagnostic tools of much greater accuracy available.

Areas covered

This review covers the advances in the treatment of seasonal AR concerning the drugs to be used according to the grade of disease and the characteristics of the patients, and the role of allergen immunotherapy (AIT), which is the only treatment capable of acting, in addition to the symptoms, on the cause of AR and therefore to modify its natural history.

Allergic multimorbidity is associated with self-reported anaphylaxis in adults—A cross-sectional questionnaire study

Tuuli Thomander, Sanna Toppila-Salmi, Johanna Salimäki, Juha Jantunen, Heini Huhtala, Paula Pallasaho, Paula Kauppi

Clin Transl Allergy. 2022 Jul 21;12(7):e12184. doi: 10.1002/clt2.12184.

Abstract

Background

Anaphylaxis has increased over the last two decades in Europe, reaching an estimated prevalence of 0.3% and an incidence of 1.5–7.9 per 100,000 person-years. Allergic multimorbidity is associated with asthma severity, yet its role in anaphylaxis is not fully understood. Our aim was to study association between allergic multimorbidity and anaphylaxis in adults.

Methods

We used population-based data from the Finnish Allergy Barometer Study (n = 2070, age range: 5–75). Food allergy (FA), atopic dermatitis (AD), allergic rhinitis (AR) and allergic conjunctivitis (AC), were defined from a self-completed questionnaire.

Dupilumab Drug Survival and Associated Predictors in Patients With Moderate to Severe Atopic Dermatitis

Long-term Results From the Daily Practice BioDay Registry

Lotte S. Spekhorst, MD¹; Marlies de Graaf, MD, PhD¹; Nicolaas P. A. Zuithoff, PhD²; et alJuul M. P. A. van den Reek, MD, PhD³; Marijke Kamsteeg, MD, PhD³; Celeste M. Boesjes, MD¹; Geertruida L. E. Romeijn⁴; Laura Loman, MD⁴; Inge Haeck, MD, PhD⁵; Albert J. Oosting, MD⁶; Astrid de Boer-Brand⁷; Wouter R. H. Touwslager, MD⁸; Annebeth Flinterman, MD, PhD⁹; Anneke M. T. van Lynden-van Nes, MD, PhD¹⁰; Antoni H. Gostynski, MD, PhD¹¹; Marjolein S. de Bruin-Weller, MD, PhD¹; Marie-Louise Schuttelaar, MD, PhD⁴

JAMA Dermatol. Published online August 10, 2022. doi:10.1001/jamadermatol.2022.3014

Key Points

Question  What is the drug survival of dupilumab in patients with atopic dermatitis (AD), and what are its associated predictors?

Findings  A total of 715 patients with AD were included with a 1-, 2-, and 3-year overall dupilumab drug survival of 90.3%, 85.9%, and 78.6%, respectively. Patients using immunosuppressive drugs at baseline and nonresponders at week 4 tended to discontinue treatment owing to ineffectiveness more frequently; using immunosuppressive drugs at baseline, older age, and very severe AD were risk factors for shorter drug survival associated with adverse effects.

Therapeutic effects elicited by the probiotic Lacticaseibacillus rhamnosus GG in children with atopic dermatitis. The results of the ProPAD trial

Carucci, L, Nocerino, R, Paparo, L, et al. Therapeutic effects elicited by the probiotic Lacticaseibacillus rhamnosus GG in children with atopic dermatitis. The results of the ProPAD trial. Pediatr Allergy Immunol. 2022; 33:e13836. doi: 10.1111/pai.13836

Abstract

Background

Atopic dermatitis (AD) is a chronic inflammatory skin disease affecting up to 20% of the pediatric population associated with alteration of skin and gut microbiome. Probiotics have been proposed for AD treatment. The ProPAD study aimed to investigate the therapeutic effects of the probiotic Lacticaseibacillus rhamnosus GG (LGG) in children with AD.

Methods

In total, 100 AD patients aged 6–36 months were enrolled in a randomized, double-blind, controlled trial to receive placebo (Group A) or LGG (1 x 1010 CFU/daily) (Group B) for 12 weeks.

A Meta Analysis of Physical Exercise on Improving Lung Function and Quality of Life Among Asthma Patients

 

Qiaoyu Zhu,1 Jianming Zhu,2 Xing Wang,3 Qiong Xu4

1School of Physical Education, Shanghai University, Shanghai, 200444, People’s Republic of China; 2Sports Department, East China University of Political Science and Law, Shanghai, 200042, People’s Republic of China; 3School of Kinesiology, Shanghai University of Sport, Shanghai, 200438, People’s Republic of China; 4School of Physical Health, Shanghai Business School, Shanghai, 201400, People’s Republic of China

J Asthma Allergy. 2022 Jul 13;15:939-955. doi: 10.2147/JAA.S369811.

Objective: This paper aims to perform a systematic assessment of the influence of physical exercise on asthma patients and discuss the intervention effects of different exercises on the lung function FEV1 (%pred) and quality of life among asthma patients so as to lay a scientific foundation for improving asthma symptoms.

Methods: Both Chinese and English databases were retrieved, including PubMed, Web of Science, Embase, The Cochrane Library, CBM, CNKI, Wan Fang Data, and VIP, whose retrieval period started from the founding date of each database to 1st, November 2021. Randomized controlled trials (RCT) studying the symptom indicators of asthma patients were collected.

Patient preferences for atopic dermatitis medications in the UK, France and Spain: a discrete choice experiment

Caitlin Thomas, Afaf Raibouaa, Andreas Wollenberg, Jean-Philippe Capron, Nicolas Krucien, Hayley Karn

BMJ Open. 2022 Aug 2;12(8):e058799. doi: 10.1136/bmjopen-2021-058799.

Abstract

Objectives We aimed to quantify patient preferences for efficacy, safety and convenience features of atopic dermatitis (AD) treatments.

Design and setting Online discrete choice experiment survey.

Participants Adults in the UK, France and Spain who had used AD treatments during the past 2 years.

Primary and secondary outcome measures Preferences for attributes were analysed using a multinomial logit model. Willingness to make trade-offs was expressed as the maximum acceptable decrease (MAD) in the probability of achieving clear/almost clear skin at week 16.

Results The survey was completed by 404 patients (44.1±12.0 years; 65% women; 64% moderate/severe eczema).

Transient and durable T cell reactivity after COVID-19

Anna Martner , Hanna Grauers Wiktorin , Andreas Törnell  +5 , Johan Ringlander, Mohammad Arabpour, Magnus Lindh, Martin Lagging, Staffan Nilsson, and Kristoffer Hellstrand

Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2203659119. doi: 10.1073/pnas.2203659119.

Abstract

This study analyzed whole blood samples (n = 56) retrieved from 30 patients at 1 to 21 (median 9) mo after verified COVID-19 to determine the polarity and duration of antigen-specific T cell reactivity against severe acute respiratory syndrome coronavirus 2–derived antigens. Multimeric peptides spanning the entire nucleocapsid protein triggered strikingly synchronous formation of interleukin (IL)-4, IL-12, IL-13, and IL-17 ex vivo until ∼70 d after confirmed infection, whereafter this reactivity was no longer inducible. In contrast, levels of nucleocapsid-induced IL-2 and interferon-γ remained stable and highly correlated at 3 to 21 mo after infection. Similar cytokine dynamics were observed in unvaccinated, convalescent patients using whole-blood samples stimulated with peptides spanning the N-terminal portion of the spike 1 protein.

A meta-analysis on randomized controlled trials of treating eosinophilic esophagitis with budesonide

Xiaopei Liu, Xue Xiao, Dan Liu & Cong’e Tan. Annals ofMedicine, 54:1, 2078-2088, DOI: 10.1080/07853890.2022.2101689

Abstract

Objective

Eosinophilic esophagitis (EoE) is a chronic, local immune-mediated inflammatory oesophageal disease. Although Budesonide is recommended as one of the first-line drugs for EoE treatment, its efficacy is still controversial in multiple studies. Due to the continuous emergence of new and reliable research evidence in recent years, we updated the meta-analysis using RCT trial results to evaluate the efficacy and safety of budesonide.

Current and Future Strategies for the Diagnosis and Treatment of the Alpha-Gal Syndrome (AGS)

J Asthma Allergy. 2022; 15: 957–970.

doi: 10.2147/JAA.S265660

Rita Vaz-Rodrigues, 1 Lorena Mazuecos, 1 and José de la Fuente 1 , 2

Abstract

The α-Gal syndrome (AGS) is a pathognomonic immunoglobulin E (IgE)-mediated delayed anaphylaxis in foods containing the oligosaccharide galactose-α-1,3-galactose (α-Gal) such as mammalian meat or dairy products. Clinical presentation of AGS can also comprise immediate hypersensitivity due to anticancer therapy, gelatin-containing vaccines or mammalian serum-based antivenom. The IgE initial sensitization is caused by hard-bodied tick bites and symptomatic individuals typically develop delayed pruritus, urticaria, angioedema, anaphylaxis, malaise or gut-related symptoms.

How Do Pollen Allergens Sensitize?

Svetlana V. Guryanova1,2, Ekaterina I. Finkina1, Daria N. Melnikova1, Ivan V. Bogdanov1, Barbara Bohle3 and Tatiana V. Ovchinnikova1,4*

• ¹Science-Educational Center, M. M. Shemyakin & Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, The Russian Academy of Sciences, Moscow, Russia
• ²Medical Institute, Peoples’ Friendship University of Russia, The Ministry of Science and Higher Education of the Russian Federation, Moscow, Russia
• ³Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
• ⁴Department of Biotechnology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia

Plant pollen is one of the main sources of allergens causing allergic diseases such as allergic rhinitis and asthma. Several allergens in plant pollen are panallergens which are also present in other allergen sources. As a result, sensitized individuals may also experience food allergies. The mechanism of sensitization and development of allergic inflammation is a consequence of the interaction of allergens with a large number of molecular factors that often are acting in a complex with other compounds, for example low-molecular-mass ligands, which contribute to the induction a type 2-driven response of immune system.