Abstract
February 4, 2023
Chronic recurrent wheals – If not chronic spontaneous urticaria, what else?
Topical cyclosporine versus allergen specific immunotherapy in perennial allergic conjunctivitis
Abstract
Purpose
Symptom control in the long-term with less side effects is important in perennial allergic conjunctivitis, since would improve quality of life. This study aimed to assess the clinical efficacies of topical cyclosporin A and subcutaneous allergen immunotherapy (SCIT) in terms of sign control in perennial allergic conjunctivitis.
Methods
This retrospective study included 20 adult patients with perennial allergic conjunctivitis and confirmed sensitization to house dust mites with skin prick test.
Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens
- Research
- Open Access
Clinical and Molecular Allergy 21, Article number: 1 (2023)
Abstract
Background
As the process and nature of developing sensitivity to house dust mites (HDMs) remain not fully studied, our goal was to establish the pattern, nature and timeframe of house dust mite (HDM) sensitization development in patients in Ukraine as well as the period when treatment of such patients would be most effective.
Methods
The data of the multiplex allergy test Alex2 was collected from 20,033 patients. To determine age specifics of sensitization, descriptive statistics were used.
February 3, 2023
Nonepisodic angioedema with eosinophilia after COVID-19 vaccination: a case successfully treated with reslizumab
- Case report
- Open Access
Allergy, Asthma & Clinical Immunology 19, Article number: 11 (2023)
Abstract
Background
Angioedema with eosinophilia (AE) is a rare allergic disease classified as episodic or nonepisodic. AE is characterized by angioedema, urticaria, fever, weight gain, and eosinophilia, but its etiology and pathogenesis have not yet been clarified.
January 31, 2023
Simulation-based education to improve management of refractory anaphylaxis in an allergy clinic
Research - Open Access
Ana M. Copaescu, Francois Graham, Nathalie Nadon, Rémi Gagnon, Arnaud Robitaille, Mohamed Badawy, David Claveau, Anne Des Roches, Jean Paradis, Matthieu Vincent & Philippe Bégin . Allergy, Asthma & Clinical Immunology volume 19, Article number: 9 (2023)
Abstract
Background
High-fidelity simulations based on real-life clinical scenarios have frequently been used to improve patient care, knowledge and teamwork in the acute care setting. Still, they are seldom included in the allergy-immunology curriculum or continuous medical education. Our main goal was to assess if critical care simulations in allergy improved performance in the clinical setting.
Methods
Advanced anaphylaxis scenarios were designed by a panel of emergency, intensive care unit, anesthesiology and allergy-immunology specialists and then adapted for the adult allergy clinic setting. This simulation activity included a first part in the high-fidelity simulation-training laboratory and a second at the adult allergy clinic involving actors and a high-fidelity mannequin.
Allergy: Mechanistic insights into new methods of prevention and therapy
Akdis CA, Akdis M, Boyd SD, Sampath V, Galli SJ, Nadeau KC. Allergy: Mechanistic insights into new methods of prevention and therapy. Sci Transl Med. 2023 Jan 18;15(679):eadd2563. doi: 10.1126/scitranslmed.add2563.
Abstract
In the past few decades, the prevalence of allergic diseases has increased worldwide. Here, we review the etiology and pathophysiology of allergic diseases, including the role of the epithelial barrier, the immune system, climate change, and pollutants. Our current understanding of the roles of early life and infancy; diverse diet; skin, respiratory, and gut barriers; and microbiome in building immune tolerance to common environmental allergens has led to changes in prevention guidelines.
January 26, 2023
Airway and parenchyma transcriptomics in a house dust mite model of experimental asthma
- Research
- Open Access
Respiratory Research 24, Article number: 32 (2023)
Abstract
January 25, 2023
Health-related quality of life decreases in young people with asthma during the transition from adolescence to young adulthood: a birth cohort study
Research - Open Access
Maria Ödling, Niklas Andersson, Christer Janson, Erik Melén, Anna Bergström & Inger Kull
BMC Pulmonary Medicine volume 23, Article number: 34 (2023)
Abstract
Background
During the transition from paediatric to adult healthcare there is a gap between asthma guidelines and actual management with decreased healthcare consultations and dispensations of asthma medications after the transition to adult healthcare among young people with asthma. How health-related quality of life (HRQoL) develops during the transition from adolescence to young adulthood is unclear. Our aim was therefore to investigate HRQoL among young people with asthma during the transition to adulthood. Further, to assess if level of asthma control and physical activity influence any potential association between asthma and HRQoL.
January 21, 2023
January 19, 2023
Cow’s milk allergy skin tests: fresh milk, commercial extracts, or both?
- Research
- Open Access
Allergy, Asthma & Clinical Immunology 19, Article number: 6 (2023)
Abstract
Background
The diagnosis of food allergy is based on a history of immediate allergic reaction following food ingestion, and skin prick test (SPT) demonstrating sensitization with commercial extracts (CE) or fresh food (FF). For most food allergens, the SPT with FF is considered more accurate and predictive. Regarding cow’s milk, the results are inconclusive. This retrospective study aimed to evaluate the accuracy of SPT with fresh milk compared to CE (cow’s milk and casein) for evaluation of cow’s milk allergy (CMA).
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