May 29, 2012

Atopic Dermatitis - Disease Etiology and Clinical Management



Atopic Dermatitis - Disease Etiology and Clinical Management

Edited by Jorge Esparza-Gordillo and Itaru Dekio, ISBN 978-953-51-0110-9, Hard cover, 414 pages, Publisher: InTech, Published: February 22, 2012 under CC BY 3.0 license, in subject Dermatology
DOI: 10.5772/1448
Atopic Dermatitis is a common disease characterized by inflamed, itching and dry skin. This relapsing allergic disorder has complex etiology and shows a remarkably high clinical heterogeneity which complicates the diagnosis and clinical management. This book is divided into 4 sections. The first section (Disease Etiology) describes some of the physiological mechanisms underlying Atopic Dermatitis, including alterations in the immune system and the skin-barrier function. The important role of host-microorganism interactions on the pathophysiology of Atopic Dermatitis is discussed in the second section (Microorganisms in Atopic Dermatitis). An overview of the clinical diagnostic criteria and the disease management protocols commonly used is given in the third section (Diagnosis and Clinical Management). The last section (New Treatments) describes new therapeutic approaches that are not widely used but are currently being studied due to preliminary evidence showing a clinical benefit for Atopic Dermatitis.

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Allergic Diseases - Highlights in the Clinic, Mechanisms and Treatment


Allergic Diseases - Highlights in the Clinic, Mechanisms and Treatment

Edited by Celso Pereira, ISBN 978-953-51-0227-4, Hard cover, 554 pages, Publisher: InTech, Published: March 14, 2012 under CC BY 3.0 license, in subject Otorhinolaryngology
DOI: 10.5772/1441
The present Edition "Allergic diseases - highlights in the clinic, mechanisms and treatment" aims to present some recent aspects related to one of the most prevalent daily clinical expression disease. The effort of a group of outstanding experts from many countries reflects a set of scientific studies very promising for a better clinical care and also to the treatment and control of the allergy. This book provides a valuable reference text in several topics of the clinical allergy and basic issues related to the immune system response. The inflammatory reaction understanding in allergic disease is clearly evidenced, as well as new strategies for further researches.

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Allergic Rhinitis Edited by Marek L. Kowalski


Allergic rhinitis, while troublesome for a patient, may be also a challenge for the physician. That is why physicians must still learn more on the pathophysiology, clinical spectrum and novel diagnostic and therapeutic approaches to the disease. The chapters of this volume address a variety of important topics related to allergic rhinitis. They begin with a description of innovative translational approaches allowing for unification of animal and human models. Contributing authors provide up-to-date reviews of clinical aspects of allergic rhinitis in children, its association with bronchial asthma and other co-morbid conditions. They also discuss the impact of allergic rhinitis on sleep and sports. Together with articles on diagnostic approaches as well as novel treatments, the book offers a comprehensive and stimulating review of the topic. May this book find a wide readership among allergists and other physicians interested in allergic disease, and also among pediatricians, general practitioners and other specialists who increasingly have to deal with this seemingly benign, but sometimes extremely troublesome, disease.

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Chronic Urticaria


Abstract


Chronic urticaria is defined as case of spontaneous wheals and/or angioedema persisting for a period of at least six weeks. The disease has an average duration of three to five years and is strongly associated with a decrease of quality of life and performance. Current international guidelines recommend the use of non-sedating antihistamines as the first choice in therapy and up-dosing these up to fourfold in cases of non-response. Alternative treatments for the afflicted who do not respond to antihistamine-treatment are also available but are not approved for use on urticaria.Image of the first page of the fulltext document
Author: Zuberbier, Torsten
Primary Title: Chronic Urticaria
Journal Name: Current Allergy and Asthma Reports
Publisher: Current Medicine Group LLC
Issn: 1529-7322
Subject: Medicine
Start Page: 1
End Page: 6
Url: http://dx.doi.org/10.1007/s11882-012-0270-7
Doi: 10.1007/s11882-012-0270-7
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May 24, 2012

Molecular allergy diagnosis: we need to become more knowledgeable.

In recent publications in the New England Journal of Medicine (concerning medicine in general), the authors state “the fundamental idea behind personalized medicine: coupling established clinical–pathological indexes with state of-the-art molecular profiling to create diagnostic, prognostic, and therapeutic strategies precisely tailored to each patient's requirements—hence the term ‘precision medicine.'” In the Annals, molecular allergy (MA) appears as welcome in traditional clinical allergy practice as the proverbial bull in a china shop, as it modifies a large number of well-established rules and beliefs. A large number of allergists have relived the experience of clinical immunologists when the first cluster of differentiation classifications entered into their clinical practice. MA language is sometimes cryptic and, for molecular allergists, being more intelligible is mandatory. For this reason, the general rules and idioms should be explained to allow “traditional” allergists to take advantage of these new (and exciting) diagnostic tools.

Giovanni Melioli, Giorgio Walter Canonica.Annals of Allergy, Asthma & Immunology, Volume 108, Issue 6 , Page 387, June 2012
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Treatment of idiopathic nonhistaminergic angioedema with bradykinin B2 receptor antagonist icatibant

Idiopathic nonhistaminergic form of angioedema (AE) is a potentially life-threatening condition. It is characterized by local swelling involving the deeper dermis and subcutaneous tissue and results from the release of mediators that cause vasodilatation and enhanced capillary permeability. Normal C1 inhibitor (INH) antigenic levels and function and normal C4 levels are the hallmark. Up to now, epidemiological studies on this form of AE are missing, and the frequency in the general population is unknown. The clinical features of this form are similar to those of hereditary AE (HAE) and acquired C1 INH deficiency. Pathophysiological evidence suggests that bradykinin is involved in HAE, in angiotensin-converting enzyme (ACE) inhibitor-induced AE, and in idiopathic nonhistaminergic AE, whereas bradykinin is not involved in allergen-dependent or idiopathic histaminergic AE that is responsive to antihistamines. The synthetic decapeptide icatibant, a selective competitive antagonist at the bradykinin B2 receptor, is authorized in Europe for the treatment of acute attacks of HAE. Recently, its successful use in severe ACE inhibitor–induced AE has been described. Its mechanism of action makes icatibant a promising drug for the idiopathic nonhistaminergic form of AE. We describe here its successful use in this condition, in which pharmacological treatment with antihistamines, corticosteroids, and epinephrine is often poorly effective.
Annals of Allergy, Asthma & Immunology. Volume 108, Issue 6 , Pages 460-461, June 2012

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August 8, 2011

ingentaconnect Human lung mast cells modulate the functions of airway smooth mus...

Human lung mast cells modulate the functions of airway smooth mus...
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July 14, 2011

The risk of occurrence of Guillain-Barré syndrome is not increased after pandemic influenza vaccine. Full text

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