Molecular Mechanisms of Nasal Epithelium in Rhinitis and Rhinosinusitis

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Abstract

Allergic rhinitis, nonallergic rhinitis, and chronic rhinosinusitis are multifactorial upper airway diseases with high prevalence. Several genetic and environmental factors are proposed to predispose to the pathogenesis of the inflammatory upper airway diseases. Still, the molecular mechanisms leading toward the onset and progression of upper airway diseases are largely unknown. The upper airway epithelium has an important role in sensing the environment and regulating the inhaled air. As such, it links environmental insults to the host immunity. Human sinonasal epithelium serves as an excellent target for observing induced early-phase events, in vivo, and with a systems biological perspective. Actually, increasing number of investigations have provided evidence that altered homeostasis in the sinonasal epithelium might be important in the chronic upper airway inflammation.

Keywords: 

Curr Allergy Asthma Rep. 2015; 15: 495.

Published online 2014 Dec 11. doi:  10.1007/s11882-014-0495-8

Sanna Toppila-Salmi, Cornelis M. van Drunen, Wytske J. Fokkens, Korneliuz Golebski, Pirkko Mattila, Sakari Joenvaara, Jutta Renkonen, and Risto Renkonen

Abstract

Allergic rhinitis, nonallergic rhinitis, and chronic rhinosinusitis are multifactorial upper airway diseases with high prevalence. Several genetic and environmental factors are proposed to predispose to the pathogenesis of the inflammatory upper airway diseases.

The Major Birch Pollen Allergen Bet v 1 Induces Different Responses in Dendritic Cells of Birch Pollen Allergic and Healthy Individuals

PLoS One. 2015 Jan 30;10(1):e0117904. doi: 10.1371/journal.pone.0117904. eCollection 2015.

Smole U1, Radauer C2, Lengger N2, Svoboda M2, Rigby N3, Bublin M2, Gaier S2, Hoffmann-Sommergruber K2, Jensen-Jarolim E4, Mechtcheriakova D2,Breiteneder H2.

Author information

Abstract

Dendritic cells play a fundamental role in shaping the immune response to allergens. The events that lead to allergic sensitization or tolerance induction during the interaction of the major birch pollen allergen Bet v 1 and dendritic cells are not very well studied.

Asian sand dust aggregate causes atopic dermatitis-like symptoms in Nc/Nga mice

Research

Sayaka Takeshita¹, Takahiro Tokunaga¹², Yoshiko Tanabe¹, Tadao Arinami¹, Takamichi Ichinose³ and Emiko Noguchi^14*

Allergy, Asthma & Clinical Immunology 2015, 11:3  doi:10.1186/s13223-015-0068-y

Published: 23 January 2015

Abstract

Background

Asian sand dust (ASD) originates from the arid and semiarid areas of China, and epidemiologic studies have shown that ASD exposure is associated with various allergic and respiratory symptoms. However, few studies have been performed to assess the relationship between skin inflammation and ASD exposure.

World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics

Position article and guidelines

Alessandro Fiocchi^1†, Ruby Pawankar^2†, Carlos Cuello-Garcia³⁴, Kangmo Ahn⁵, Suleiman Al-Hammadi⁶, Arnav Agarwal³⁷, Kirsten Beyer⁸, Wesley Burks⁹, Giorgio W Canonica¹⁰,Motohiro Ebisawa¹¹, Shreyas Gandhi³⁷, Rose Kamenwa¹², Bee Wah Lee¹³, Haiqi Li¹⁴,Susan Prescott¹⁵, John J Riva¹⁶, Lanny Rosenwasser¹⁷, Hugh Sampson¹⁸, Michael Spigler¹⁹, Luigi Terracciano²⁰, Andrea Vereda-Ortiz²², Susan Waserman²¹, Juan José Yepes-Nuñez³, Jan L Brożek^213* and Holger J Schünemann²¹³

World Allergy Organization Journal 2015, 8:4  doi:10.1186/s40413-015-0055-2

Published: 27 January 2015

Abstract

Background

Prevalence of allergic diseases in infants, whose parents and siblings do not have allergy, is approximately 10% and reaches 20–30% in those with an allergic first-degree relative. Intestinal microbiota may modulate immunologic and inflammatory systemic responses and, thus, influence development of sensitization and allergy. Probiotics have been reported to modulate immune responses and their supplementation has been proposed as a preventive intervention.

Differences in the clinical and radiological characteristics of lung-involved toxocariasis between toxocariasis with eosinophilia and those without eosinophilia

 
• Vol 6, No 12 (December 2014) 

Authors: Bo Mi Park, Sang Ok Jeong, Hee Sun Park, Sung Soo Jung, Sun Young 

Kim, Ju Ock Kim, Jeong Eun Lee

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Abstract

Background: Previously, most studies did not discuss about the characteristics of lung-involved toxocariasis without eosinophilia. However, the patients are not always accompanied by eosinophilia, so it is necessary to learn about the clinical and radiologic features that may predict pulmonary toxocariasis without eosinophilia.

Microbial contamination of domiciliary nebulisers and clinical implications in chronic obstructive pulmonary disease

BMJ Open Resp Res 2014;1:e000018 doi:10.1136/bmjresp-2013-000018

1. S Jarvis1, 
2. P W Ind1, 
3. C Thomas2, 
4. S Goonesekera2, 
5. R Haffenden3, 
6. A Abdolrasouli2,
7. F Fiorentino4 and 
8. R J Shiner1

1. ¹Department of Respiratory Medicine, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK
2. ²Department of Microbiology, Hammersmith Hospital, London, UK
3. ³Central London Community Healthcare NHS Trust (CLCH), Charing Cross Hospital, London, UK
4. ⁴NHLI, Department of Cardiothoracic Surgery, Hammersmith Hospital, Imperial College, London, UK
5. 
   

Abstract

Background and purpose Domiciliary nebulisers are widely used in chronic obstructive pulmonary disease (COPD) but nebuliser cleaning practice has not been assessed in patients with COPD who are often elderly and may have severe disease and multiple comorbidities. We aimed to evaluate microbial contamination of home nebulisers used by patients with COPD.

Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement

Research

David Moher^1*, Larissa Shamseer¹, Mike Clarke², Davina Ghersi³, Alessandro Liberati,Mark Petticrew⁴, Paul Shekelle⁵, Lesley A Stewart⁶ and PRISMA-P Group

Systematic Reviews 2015, 4:1  doi:10.1186/2046-4053-4-1

Published: 1 January 2015

Abstract

Systematic reviews should build on a protocol that describes the rationale, hypothesis, and planned methods of the review; few reviews report whether a protocol exists.

Removal of peanut allergen Ara h 1 from common hospital surfaces, toys and books using standard cleaning methods

Research

Published: 23 January 2015

Wade TA Watson, AnnMarie Woodrow and Andrew W Stadnyk

Allergy, Asthma & Clinical Immunology 2015, 11:4  doi:10.1186/s13223-015-0069-x

Abstract (provisional)

Background

In children, a diagnosis of peanut allergy causes concern about accidental exposure because even small amounts of peanut protein could trigger an allergic reaction.