September 6, 2018

Treatment with the SQ house dust mite sublingual immunotherapy tablet may be initiated year-round

Value of a Second Dose of Epinephrine During Anaphylaxis: A Patient/Caregiver Survey

Background

Anaphylaxis guidelines recommend prescription of more than 1 epinephrine autoinjector (EAI) for patients at risk. A second epinephrine dose is required in 16% to 36% of patients.

August 31, 2018

Prevalence of allergic sensitization, hay fever, eczema, and asthma in a longitudinal birth cohort

Authors Owens L, Laing IA, Zhang GTurner S, Le Souëf PN
Received 9 April 2018
Accepted for publication 4 May 2018
Published 13 August 2018 Volume 2018:11 Pages 173—180
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 2
Editor who approved publication: Dr Luis Garcia-Marcos
Article has an altmetric score of 12

Louisa Owens,1,2 Ingrid A Laing,3,4 Guicheng Zhang,5,6 Stephen Turner,7 Peter N Le Souëf1

1School of Medicine, University of Western Australia, Perth, WA, Australia; 2School of Women’s and Children’s Health, University of New South Wales, Sydney, NSW, Australia; 3Telethon Kids Institute, Perth, WA, Australia; 4School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia; 5School of Public Health, Curtin University, Perth, WA, Australia; 6Centre for Genetic Origins of Health and Disease, University of Western Australia, Perth, WA, Australia; 7School of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK

August 28, 2018

Effects of nasal dilator strips on subjective measures of sleep in subjects with chronic nocturnal nasal congestion: a randomized, placebo-controlled trial

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Background
This exploratory study investigated effects of a new asymmetric butterfly-shaped prototype nasal dilator strip and the currently marketed clear Breathe Right Nasal Strip (BRNS) on subjective measures of nasal congestion and sleep quality.

August 22, 2018

The Role of Interleukin-19 in Contact Hypersensitivity.

Fujimoto Y, et al. Biol Pharm Bull. 2018.

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Abstract

Interleukin (IL)-19 is a member of the IL-10 family of interleukins and is an immuno-modulatory cytokine produced by the main macrophages. The gastrointestinal tissues of IL-19 knockout mice show exacerbated experimental colitis mediated by the innate immune system and T cells.

August 21, 2018

Unintentional injection to the bone with a pediatric epinephrine auto-injector

  • Allergy, Asthma & Clinical Immunology
  • Case report
  • Open Access

Abstract
Background
Skin-to-bone distance (STBD) in children prescribed a pediatric epinephrine auto-injector (EAI) for anaphylaxis is not commonly measured in practice. Recent evidence suggests that children with STBD less than the exposed needle length of available pediatric EAIs (dose: 0.15 mg, needle length: 12.7 mm) are at risk for unintentional injections to the bone during their use for an allergic emergency.

August 19, 2018

Risk of childhood cerebral palsy following prenatal exposure to ß2-adrenergic receptor agonist: A nationwide cohort study

PLoS One. 2018 Aug 16;13(8):e0202078.
    Lin Li, Ziliang Wang , Hong Liang, Fen Yang, Wei Yuan, Bizu Gelaye, Yongfu Yu, Maohua Miao , Mette Nørgaard, Jiong Li
Abstract
Background
Cerebral palsy (CP) is the most common physical developmental disability in childhood with a prevalence of 2 to 3 per 1000 live births. β2-adrenoreceptor agonist (β2AA) are widely used for the treatment of asthma. Maternal use of β2AAs may increase the risk of adverse neuro-psychiatric health outcomes in the offspring. No study, however, has evaluated the effect of prenatal exposure to β2AAs on the risk of CP.

August 16, 2018

Effectiveness of clarithromycin in patients with yellow nail syndrome

  • Research article
  • Open Access
  • Open Peer Review
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Open Peer Review reports

Abstract

Background
Yellow nail syndrome (YNS) is a rare disease characterized by the triad of thickened, slow-growing yellow nails, lymphedema, and chronic respiratory manifestations. The cause of YNS is not known; however, it is suggested to be due to a congenital lymph abnormality. Since YNS is accompanied by chronic bronchial infection in more than half of patients, we hypothesized that treatment with clarithromycin (CAM) could be effective.