September 10, 2018

Common allergies in urban adolescents and their relationships with asthma control and healthcare utilization

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Allergy, Asthma & Clinical Immunology201814:33

Urban adolescents suffer a disproportionate burden of asthma morbidity, often in association with allergies. Literature is limited on comparing various types of allergies regarding prevalence and associations with asthma morbidity in urban dwelling adolescents. The purpose of this study was to examine the prevalence of common allergies reported by urban adolescents and to assess their relationships to healthcare utilization and asthma control.

September 8, 2018

Association Between Use of Acid-Suppressive Medications and Antibiotics During Infancy and Allergic Diseases in Early Childhood


Edward Mitre, MD1; Apryl Susi, MS2; Laura E. Kropp, MPH1; et alDavid J. Schwartz, MD3; Gregory H. Gorman, MD2; Cade M. Nylund, MD2

JAMA Pediatr. 2018;172(6):e180315. doi:10.1001/jamapediatrics.2018.0315

Key Points

Question Does use of medications that disturb the microbiome in infancy increase subsequent risk of developing allergic diseases?

Findings In this cohort study of 792 130 children, the hazard of developing an allergic disease was significantly increased in those who had received acid-suppressive medications or antibiotics during the first 6 months of life.

September 6, 2018

Conjunctivitis occurring in atopic dermatitis patients treated with dupilumab–clinical characteristics and treatment

Treatment with the SQ house dust mite sublingual immunotherapy tablet may be initiated year-round

Value of a Second Dose of Epinephrine During Anaphylaxis: A Patient/Caregiver Survey

Background

Anaphylaxis guidelines recommend prescription of more than 1 epinephrine autoinjector (EAI) for patients at risk. A second epinephrine dose is required in 16% to 36% of patients.

August 31, 2018

Prevalence of allergic sensitization, hay fever, eczema, and asthma in a longitudinal birth cohort

Authors Owens L, Laing IA, Zhang GTurner S, Le Souëf PN
Received 9 April 2018
Accepted for publication 4 May 2018
Published 13 August 2018 Volume 2018:11 Pages 173—180
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 2
Editor who approved publication: Dr Luis Garcia-Marcos
Article has an altmetric score of 12

Louisa Owens,1,2 Ingrid A Laing,3,4 Guicheng Zhang,5,6 Stephen Turner,7 Peter N Le Souëf1

1School of Medicine, University of Western Australia, Perth, WA, Australia; 2School of Women’s and Children’s Health, University of New South Wales, Sydney, NSW, Australia; 3Telethon Kids Institute, Perth, WA, Australia; 4School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia; 5School of Public Health, Curtin University, Perth, WA, Australia; 6Centre for Genetic Origins of Health and Disease, University of Western Australia, Perth, WA, Australia; 7School of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK

August 28, 2018

Effects of nasal dilator strips on subjective measures of sleep in subjects with chronic nocturnal nasal congestion: a randomized, placebo-controlled trial

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Background
This exploratory study investigated effects of a new asymmetric butterfly-shaped prototype nasal dilator strip and the currently marketed clear Breathe Right Nasal Strip (BRNS) on subjective measures of nasal congestion and sleep quality.

August 22, 2018

The Role of Interleukin-19 in Contact Hypersensitivity.

Fujimoto Y, et al. Biol Pharm Bull. 2018.

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Abstract

Interleukin (IL)-19 is a member of the IL-10 family of interleukins and is an immuno-modulatory cytokine produced by the main macrophages. The gastrointestinal tissues of IL-19 knockout mice show exacerbated experimental colitis mediated by the innate immune system and T cells.