Long term management of obstructive sleep apnea and its comorbidities

Multidisciplinary Respiratory Medicine
•  Review
• Open Access

• Marta Marin-Oto,
• Eugenio E. Vicente and
• Jose M. MarinEmail author

Multidisciplinary Respiratory Medicine201914:21

Abstract

Obstructive sleep apnea (OSA) is a worldwide highly prevalent disease associated with systemic consequences, including excessive sleepiness, impairment of neurocognitive function and daytime performance, including driving ability. The long-term sequelae of OSA include and increase risk for cardiovascular, cerebrovascular and metabolic syndrome disorders that ultimately lead to premature death if untreated. To ensure optimal long-term outcomes, the assessment and management of OSA should be personalized with the involvement of the appropriate specialist. Most studies have demonstrated immediate improvement in daytime somnolence and quality of life with CPAP and other therapies, but the effect of long-term treatment on mortality is still under debate.

Ambient air pollution and respiratory mortality in Xi’an, China: a time-series analysis

Respiratory Research
• 
  
• Research
• Open Access

• Kingsley Katleho Mokoena,
• Crystal Jane Ethan,
• Yan YuView ORCID ID profile,
• Karabo Shale and
• Feng LiuEmail author

Respiratory Research201920:139

 Abstract

Background

Although air pollution is a known fundamental problem in China, few studies have investigated the associations between ambient air pollution and respiratory mortality in non-metropolitan cities of China. The study aimed to investigate a potential relationship between short-term exposure to ambient air pollutants and respiratory mortality in Xi’an, China.

Emerging Therapies in Chronic Spontaneous Urticaria

Allergy Asthma Immunol Res. 2019 Jul;11(4):470-481. English.

Taek Ki Min,1 and Sarbjit S. Saini2

1Pediatric Allergy and Respiratory Center, Department of Pediatrics, Soonchunhyang University Seoul Hospital, Seoul, Korea.

2Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Abstract

Chronic spontaneous urticaria (CSU) is characterized by typically short-lived and fleeting wheals, angioedema or both, which occur spontaneously and persist for longer than 6 weeks. This term is applied to the most common subtype of chronic urticaria. The underlying pathophysiology for CSU involves mast cell and basophil degranulation with release of histamine, leukotrienes, prostaglandins and other inflammatory mediators. Although a variety of treatments exist, many patients do not tolerate or benefit from the existing therapies and even require more effective treatments. Omalizumab is currently the only licensed biologic for antihistamine-refractory CSU, and novel drugs are under development. This article reviews its current status regarding pathogenesis and approach to treatment as well as therapeutic agents that are under development for the treatment of CSU. PDF

The Role of Mobile Health Technologies in Allergy Care: an EAACI Position Paper

EAACI Position Paper 

 

Free Access

https://doi.org/10.1111/all.13953

Matricardi, P. M., Dramburg, S. , Alvarez‐Perea, A. , Antolín‐Amérigo, D. , Apfelbacher, C. , Atanaskovic‐Markovic, M. , Berger, U. , Blaiss, M. S., Blank, S. , Boni, E. , Bonini, M. , Bousquet, J. , Brockow, K. , Buters, J. , Cardona, V. , Caubet, J. , Cavkaytar, Ö. , Elliott, T. , Esteban‐Gorgojo, I. , Fonseca, J. A., Gardner, J. , Gevaert, P. , Ghiordanescu, I. , Hellings, P. , Hoffmann‐Sommergruber, K. , Kalpaklioglu, A. F., Marmouz, F. , Meijide Calderón, Á. , Mösges, R. , Nakonechna, A. , Ollert, M. , Oteros, J. , Pajno, G. , Panaitescu, C. , Perez‐Formigo, D. , Pfaar, O. , Pitsios, C. , Rudenko, M. , Ryan, D. , Sánchez‐García, S. , Shih, J. , Tripodi, S. , Van der Poel, L. , van Os‐Medendorp, H. , Varricchi, G. , Wittmann, J. , Worm, M. and Agache, I. (2019), The Role of Mobile Health Technologies in Allergy Care: an EAACI Position Paper. Allergy. Accepted Author Manuscript. doi:10.1111/all.13953

Abstract:

Mobile Health (mHealth) uses mobile communication devices such as smartphones and tablet computers to support and improve health‐related services, data flow and information, patient self‐management, surveillance, and disease management from the moment of first diagnosis to an optimized treatment. The European Academy of Allergy and Clinical Immunology created a task force to assess the state of the art and future potential of mHealth in allergology. The task force endorsed the “Be He@lthy, Be Mobile” WHO initiative and debated the quality, usability, efficiency, advantages, limitations, and risks of mobile solutions for allergic diseases.

Antibiotic overuse and allergy-related diseases: an epidemiological cross-sectional study in the grasslands of Northern China

 Therapeutics and Clinical Risk Management » Volume 15

Yan Lei Chen,¹ Weirong Joshua Sng,² De Yun Wang,² Xue Yan Wang¹

¹Department of Allergy, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; ²Department of Otolaryngology, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
DOI https://doi.org/10.2147/TCRM.S203719
Background: Several studies have shown that the use of antibiotics early in life significantly increases the risk of asthma in children. It is unclear whether antibiotics are more commonly used in patients with allergy-related diseases.

Sesame oleosins are minor allergens

• Letter to the Editor
• Open Access

• Anna M. EhlersEmail authorView ORCID ID profile,
• Madlen Rossnagel,
• Bettina Brix,
• Mark A. Blankestijn,
• Thuy-My Le,
• Waltraud Suer,
• Henny G. Otten and
• André C. Knulst

Western blot analysis of native sesame OAPs fraction to confirm the absence of seed storage protein traces (a) and the specific IgE (b) and IgG sensitisation pattern (c) of all included patients. a Western-Blot analysis of an intermediate purification step (before HIC) and of the final OAPs fraction (after HIC) with sera containing sIgE to sesame seed storage proteins and oleosins. Samples were separated by SDS-PAGE using a 4–12% Bis–Tris gel and blotted onto a nitrocellulose membrane. Bound IgE were detected by anti-human IgE antibodies conjugate labelled with alkaline phosphatase; PC is a oleosin-positive serum, SP is a sesame seed storage positive serum not used in this study, sera G1b_1, 4, 14, 11, 15–18, G2_12 and 10 are sera with specific IgE to sesame seed storage proteins and partly with slightly elevated sIgE levels to sesame oleosins. b IgE sensitisation pattern to sesame extract from ImmunoCAP and EUROLINE, sesame components and oleosins from sesame, walnut, soy, hazelnut and peanut expressed as EAST (Enzyme-Allergo-Sorbent Test classification)-classes and sorted by severity of symptoms to sesame, light grey: not determined. c IgG-sensitisation pattern to sesame components and oleosins from sesame, walnut, pecan and soy expressed as EUROLINE (EL)-intensities and sorted by severity of symptoms to sesame. G1a sesame allergic patients without detectable sIgE sensitisation, G1b sesame allergic patients with sIgE sensitisation, G2 sesame tolerant patients with sIgE sensitisation, PC positive control selected by sIgE to sesame oleosins, C1-3 positive controls selected by sIgE to peanut oleosins

Clinical and Translational Allergy20199:32

Abstract

Background

In daily practice, one-third of sesame allergic patients, confirmed by clinical history or food challenge, do not show any detectable specific IgE using current diagnostics. Currently used sesame extracts are water-based and therefore lacking hydrophobic proteins like oleosins.

Management of suspected immediate perioperative allergic reactions: an international overview and consensus recommendations

July 2019Volume 123, Issue 1, Pages e50–e64

Lene H. Garvey1,2,∗,Correspondence information about the author Lene H. Garvey†,‡,Email the author Lene H. Garvey

, 

Pascale Dewachter3,4,†,‡

, 

David L. Hepner5,†,‡

, 

Paul Michel Mertes6,†,‡

, 

Susanna Voltolini7,†,‡

, 

Russell Clarke8,9,‡

, 

Peter Cooke10,‡

, 

Tomaz Garcez11,‡

, 

Anne Berit Guttormsen12,‡

, 

Didier G. Ebo13,‡

, 

Philip M. Hopkins14,‡

, 

David A. Khan15,‡

, 

Peter Kopac16,‡

, 

Mogens Krøigaard1,‡

, 

Jose Julio Laguna17,‡

, 

Stuart Marshall18,19,‡

, 

Peter Platt8,9,‡

, 

Michael Rose20,‡

, 

Vito Sabato13,‡

, 

Paul Sadleir8,9,21,‡

, 

Louise Savic22,‡

, 

Sinisa Savic23,‡

, 

Kathrin Scherer24,‡

, 

Tomonori Takazawa25,‡

, 

Gerald W. Volcheck26,‡

, 

Helen Kolawole18,19,†,‡

PlumX Metrics

DOI: https://doi.org/10.1016/j.bja.2019.04.044

Article Info

• Abstract

• Full Text
• Images
• References
• Supplemental Materials

Summary

Suspected perioperative allergic reactions are rare but can be life-threatening. The diagnosis is difficult to make in the perioperative setting, but prompt recognition and correct treatment is necessary to ensure a good outcome. A group of 26 international experts in perioperative allergy (anaesthesiologists, allergists, and immunologists) contributed to a modified Delphi consensus process, which covered areas such as differential diagnosis, management during and after anaphylaxis, allergy investigations, and plans for a subsequent anaesthetic. They were asked to rank the appropriateness of statements related to the immediate management of suspected perioperative allergic reactions.

Emerging Therapies in Chronic Spontaneous Urticaria

Allergy Asthma Immunol Res. 2019 Jul;11(4):470-481. https://doi.org/10.4168/aair.2019.11.4.470

Taek Ki Min,1 and Sarbjit S. Saini2

1Pediatric Allergy and Respiratory Center, Department of Pediatrics, Soonchunhyang University Seoul Hospital, Seoul, Korea.

2Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Abstract

Chronic spontaneous urticaria (CSU) is characterized by typically short-lived and fleeting wheals, angioedema or both, which occur spontaneously and persist for longer than 6 weeks. This term is applied to the most common subtype of chronic urticaria. The underlying pathophysiology for CSU involves mast cell and basophil degranulation with release of histamine, leukotrienes, prostaglandins and other inflammatory mediators. Although a variety of treatments exist, many patients do not tolerate or benefit from the existing therapies and even require more effective treatments. Omalizumab is currently the only licensed biologic for antihistamine-refractory CSU, and novel drugs are under development. This article reviews its current status regarding pathogenesis and approach to treatment as well as therapeutic agents that are under development for the treatment of CSU. PDF