Does unified allergic airway disease impact on lung function and type 2 biomarkers?

• Letter to the editor
• Open Access
• Allergy, Asthma & Clinical Immunology

• Chris RuiWen Kuo, 
• Rory Chan & 
• Brian Lipworth 

Allergy, Asthma & Clinical Immunology volume 15, Article number: 75 (2019) 

• details

Abstract

Values are shown as means and standard error of means
for significant comparisons between allergic asthma with and without
allergic rhinitis according to a FEV1% predicted,
b FEF25–75% predicted, c FeNO and d blood eosinophils

The concept of the unified allergic airway disease (UAD) recognises the association between allergic inflammation in the upper and lower airways. Patients with asthma and concomitant allergic rhinitis experience more asthma-related primary and secondary care visits. We therefore aimed to determine differences in asthma control (asthma control questionnaire ACQ-6), lung function (spirometry) and T2 biomarkers (FeNO and Eos) in relation to the presence of allergic rhinitis in patients with allergic asthma.

Short-term skin problems in infants aged 0–3 months affect food allergies or atopic dermatitis until 2 years of age, among infants of the general population

• Research
• Open Access
• 
  

Allergy, Asthma & Clinical Immunology

• Kaori Yonezawa & 
• Megumi Haruna 

Allergy, Asthma & Clinical Immunology volume 15, Article number: 74 (2019) 

Abstract

Background

This study examined whether infants aged 0–3 months exhibited long-term effects of using a moisturizer skincare intervention and whether a short-term skin problem resulted in the subsequent development of food allergies or atopic dermatitis (AD) until the age of 2 years.

The International/Canadian Hereditary Angioedema Guideline

• Review
• Open Access

Allergy, Asthma & Clinical Immunology

Stephen Betschel, 

Jacquie Badiou, 

[…]

Ellie Tsai 

Allergy, Asthma & Clinical Immunology volume 15, Article number: 72 (2019) 

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Abstract

This is an update to the 2014 Canadian Hereditary Angioedema Guideline with an expanded scope to include the management of hereditary angioedema (HAE) patients worldwide. It is a collaboration of Canadian and international HAE experts and patient groups led by the Canadian Hereditary Angioedema Network. The objective of this guideline is to provide evidence-based recommendations, using the GRADE system, for the management of patients with HAE.

Agreement between self-reported asthma symptoms and exhaled nitric oxide levels: impact on inhaled corticosteroid prescribing in general practice. An observational study

• Research
• Open Access

Allergy, Asthma & Clinical Immunology

• Raj Gill & 
• E. Mark Williams 

Allergy, Asthma & Clinical Immunology volume 15, Article number: 70 (2019) 

Abstract

Background

A box-plot of FeNO levels. The median is shown with 25–75th percentile.
An outlier of 279 is included in the analysis but not shown

The National Review of Asthma Deaths UK highlighted that 46% of deaths could be avoided and recommended that all sufferers receive a structured asthma annual review which assess asthma control. In primary care this is commonly achieved using symptom-based questionnaires such as the Asthma Control Test (ACT). A newer method of assessing asthma control is Fractional Exhaled Nitric Oxide (FeNO) testing, which is currently recommended for the diagnosis of asthma, but not for monitoring of asthma control.

Immunostimulants in respiratory diseases: focus on Pidotimod

Multidisciplinary Respiratory Medicine

• Francesca Puggioni, 
• Magna Alves-Correia, 
• Manar-Farouk Mohamed, 
• Niccolò Stomeo, 
• Riccardo Mager, 
• Massimiliano Marinoni, 
• Francesca Racca, 
• Giovanni Paoletti, 
• Gilda Varricchi, 
• Veronica Giorgis, 
• Giovanni Melioli, 
• Giorgio Walter Canonica & 
• Enrico Heffler 

Multidisciplinary Respiratory Medicine volume 14, Article number: 31 (2019)

Abstract

Immunological activities of Pidotimod

Usefulness of Pidotimod and its role as immunostimulant, has been discussed, we know, for several decades. Nevertheless, there is still much to know. Understanding its mechanisms and its potential usefulness in airway infections and its prevention, asthma both Th2 and non Th2 type, bronchiectasis, as adjuvant in vaccination and in allergen immunotherapy still remains to clearly unveil. The aim of this paper was to provide a useful updated review of the role of the main available immunostimulants, giving particular focus on Pidotimod use and its potentials utility in respiratory diseases.

Adherence to adrenaline autoinjector prescriptions in patients with anaphylaxis

• Research Letter
• Open Access
• 
  

Clinical and Translational Allergy

• Louise Parke, 
• Annemarie Schaeffer Senders, 
• Carsten Bindslev-Jensen, 
• Annmarie Touborg Lassen, 
• Athamaica Ruiz Oropeza, 
• Susanne Halken, 
• Sigurd Broesby-Olsen, 
• Henrik Fomsgaard Kjær & 
• Charlotte G. Mortz 

Clinical and Translational Allergy volume 9, Article number: 59 (2019) 

• details

Percentage of retrieved adrenaline autoinjectors
in relation to age

Abstract

This study evaluates adherence to adrenaline autoinjector prescriptions in a cohort of well-characterized anaphylaxis patients. The overall retrieval rate was 76% with the highest rate in patients with severe anaphylaxis. Special attention is needed in patients with unknown elicitors and in young adults, comprising the largest proportion of non-adherent patients.

Trial registration No intervention performed. Retrospective data used with permission from the Danish Data Protection Agency and Regional Committees on Health Research Ethics.

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Review of the Manitoba cohort of patients with hereditary angioedema with normal C1 inhibitor

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  Allergy, Asthma & Clinical Immunology
• Research
• Open Access

• Lundy McKibbin, 
• Colin Barber, 
• Chrystyna Kalicinsky & 
• Richard Warrington 

Allergy, Asthma & Clinical Immunology volume 15, Article number: 66 (2019)

Abstract

Background

Hereditary angioedema with normal C1 inhibitor (HAE-nC1 INH) is a rare, underappreciated condition characterized by recurrent subcutaneous angioedema. The underlying pathophysiology and diagnostic criteria continues to evolve. There is a significant overlap between HAE-nC1 INH and idiopathic nonhistaminergic angioedema, ultimately this may be found to be the same condition. Characterization of cohorts suspected to have either of these conditions is warranted to help refine diagnosis, pathophysiology, and treatment response.

Methods

Review of the Manitoba cohort of patients
with HAE-nC1 INH: inclusion criteria

A retrospective chart review of 418 patients diagnosed with angioedema was conducted.

The safety and tolerability profile of bilastine for chronic urticaria in children

• Clinical and Translational Allergy
• Review
• Open Access

• Nikolaos G. Papadopoulos & 
• Torsten Zuberbier 

Clinical and Translational Allergy volume 9, Article number: 55 (2019) 

• details

Abstract

Background

Urticaria is a condition defined by the development of wheals, angioedema or both. It is classified based on its duration as acute (≤ 6 weeks) or chronic (> 6 weeks). Chronic urticaria is less frequent than acute one in children, but it represents a debilitating condition, always needing treatment. Symptoms affect child’s daily activities and disturb sleeping patterns, causing emotional distress and negatively influencing learning and cognition.