Interleukin-22 attenuates allergic airway inflammation in ovalbumin-induced asthma mouse model

• Research
• Open Access

• Jingru Wang, 
• Shengnan Gao, 
• Jingyuan Zhang, 
• Chunxiao Li, 
• Hongwen Li & 
• Jiangtao Lin 

BMC Pulmonary Medicine volume 21, Article number: 385 (2021) 

• details

Abstract

Background

Allergic asthma is a chronic airway inflammatory disease with a number of cytokines participating in its pathogenesis and progress. Interleukin (IL)-22, which is derived from lymphocytes, acts on epithelial cells and play a role in the chronic airway inflammation. However, the actual role of IL-22 in allergic asthma is still unclear. Therefore, we explored the effect of IL-22 on allergic airway inflammation and airway hyperresponsiveness (AHR) in an ovalbumin (OVA)-induced asthma mouse model.

Volatile organic breath components and exercise induced bronchoconstriction in asthmatic children

• Research
• Open Access
• 
  

• M. R. van der Kamp, 
• J. M. M. Driessen, 
• M. P. van der Schee, 
• B. J. Thio & 
• F. H. C. de Jongh 

Allergy, Asthma & Clinical Immunology volume 17, Article number: 121 (2021) 

• details

Abstract

Introduction

Asthma is one of the most common chronic diseases in childhood and is generally characterized by exercise induced bronchoconstriction (EIB). Assessing EIB is time consuming and expensive as it requires a fully equipped pulmonary function laboratory. Analysis of volatile organic compounds (VOCs) in breath is a novel technique for examining biomarkers which may associate with asthma features. The aim of this pilot study was to identify potential markers in the relationship between EIB and VOCs.

Pulmonary eosinophilia may indicate onset stage of allergic bronchopulmonary aspergillosis

• Research
• Open Access
• 
  

• Mari Miki, 
• Yuko Ohara, 
• Kazuyuki Tsujino, 
• Takahiro Kawasaki, 
• Tomoki Kuge, 
• Yuji Yamamoto, 
• Takanori Matsuki, 
• Keisuke Miki & 
• Hiroshi Kida 

Allergy, Asthma & Clinical Immunology volume 17, Article number: 118 (2021) 

Abstract

Background

Allergic bronchopulmonary aspergillosis (ABPA) and chronic eosinophilic pneumonia (CEP) both display peripheral eosinophilia as well as pulmonary infiltration, together described as pulmonary eosinophilia, and differentiation is sometimes problematic. This study therefore examined the distinctions between ABPA with and without CEP-like shadows.

Differential uptake of three clinically relevant allergens by human plasmacytoid dendritic cells

• Research
• Open Access

• Noelle Zurmühl, 
• Anna Schmitt, 
• Ulrike Formentini, 
• Johannes Weiss, 
• Heike Appel, 
• Klaus-Michael Debatin & 
• Dorit Fabricius 

Clinical and Molecular Allergy volume 19, Article number: 23 (2021) 

Abstract

Background

Human plasmacytoid dendritic cells (pDC) have a dual role as interferon-producing and antigen-presenting cells. Their relevance for allergic diseases is controversial. and the impact of pDC on allergic immune responses is poorly understood.

Induction of remission in chronic urticaria by immunotherapy using immunoglobulin/histamine complex (Histobulin™): a case report

• Case Report
• Open Access
• Published: 12 November 2021

• Hyuk Soon Kim & 
• Geunwoong Noh 

Allergy, Asthma & Clinical Immunology volume 17, Article number: 116 (2021)

• details

Abstract

Background

Symptom control is a major concern in chronic urticaria. Histobulin™ is a histamine/immunoglobulin complex that has been approved for allergic rhinitis, bronchial asthma and chronic urticaria in some countries. Not only has the immunoglobulin/histamine complex been reported to be effective in allergic diseases, including chronic urticaria, but recently, the possibility of remission induction in chronic urticaria by the immunoglobulin/histamine complex has been reported.

The cellular composition of the lung lining fluid gradually changes from bronchus to alveolus

• Letter to the Editor
• Open Access
• 
  

• S. D. Pouwels, 
• Janette K. Burgess, 
• Erik Verschuuren & 
• Dirk-Jan Slebos 

Respiratory Research volume 22, Article number: 285 (2021)

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Abstract

Although large advances have recently been made mapping out the cellular composition of lung tissue using single cell sequencing, the composition and distribution of the cellular elements within the lining fluid of the lung has not been extensively studied. Here, we assessed the cellular composition of the lung lining fluid by performing a differential cell analysis on bronchoalveolar lavage fluid (BALF) and epithelial lining fluid (ELF) at four different locations within the lung in post-lung transplantation patients. The percentage of neutrophils and lymphocytes is reduced in more distal regions of the lungs, while the percentage of macrophages increases in these more distal regions.

Long-term predictors of severe exacerbations and mortality in a cohort of well-characterised adults with asthma

• Research
• Open Access
• 
  

• Oliver Djurhuus Tupper & 
• Charlotte Suppli Ulrik 

Respiratory Research volume 22, Article number: 269 (2021) 

• details

Abstract

Background

We aimed to explore long-term predictors of severe exacerbations and mortality in adults with well-characterised asthma.

Association between particulate matter containing EPFRs and neutrophilic asthma through AhR and Th17

• Respiratory Research  
• Open Access
• 
  

• Jeffrey N. Harding, 
• Maureen Gross, 
• Vivek Patel, 
• Steven Potter & 
• Stephania A. Cormier 

Respiratory Research volume 22, Article number: 275 (2021) 

• details

Abstract

Background

Epidemiological data associate high levels of combustion-derived particulate matter (PM) with deleterious respiratory outcomes, but the mechanism underlying those outcomes remains elusive. It has been acknowledged by the World Health Organization that PM exposure contributes to more than 4.2 million all-cause mortalities worldwide each year. Current literature demonstrates that PM exacerbates respiratory diseases, impairs lung function, results in chronic respiratory illnesses, and is associated with increased mortality.