August 15, 2022

Prevalence of reported food allergies in Brazilian preschoolers living in a small Brazilian city

  • Research
  • Open Access


Allergy, Asthma & Clinical Immunology volume 18, Article number: 74 (2022

August 12, 2022

Current treatment strategies for seasonal allergic rhinitis: where are we heading?


Erminia Ridolo, Cristoforo Incorvaia, Francesco Pucciarini, Elena Makri, Giovanni Paoletti & Giorgio Walter Canonica 

Clinical and Molecular Allergy volume 20, Article number: 9 (2022) 



Abstract

Introduction

Allergic rhinitis (AR) is very commonly caused by pollens. The symptoms of AR consist of sneezing, nasal congestion, rhinorrhea, nasal itching and airflow obstruction. The diagnosis has long been based on clinical history, skin prick tests and in vitro measurement of specific IgE, but the innovative approach of precision medicine has made diagnostic tools of much greater accuracy available.

Areas covered

This review covers the advances in the treatment of seasonal AR concerning the drugs to be used according to the grade of disease and the characteristics of the patients, and the role of allergen immunotherapy (AIT), which is the only treatment capable of acting, in addition to the symptoms, on the cause of AR and therefore to modify its natural history.

Allergic multimorbidity is associated with self-reported anaphylaxis in adults—A cross-sectional questionnaire study

Tuuli Thomander, Sanna Toppila-Salmi, Johanna Salimäki, Juha Jantunen, Heini Huhtala, Paula Pallasaho, Paula Kauppi


Clin Transl Allergy. 2022 Jul 21;12(7):e12184. doi: 10.1002/clt2.12184.

Abstract

Background

Anaphylaxis has increased over the last two decades in Europe, reaching an estimated prevalence of 0.3% and an incidence of 1.5–7.9 per 100,000 person-years. Allergic multimorbidity is associated with asthma severity, yet its role in anaphylaxis is not fully understood. Our aim was to study association between allergic multimorbidity and anaphylaxis in adults.

Methods

We used population-based data from the Finnish Allergy Barometer Study (n = 2070, age range: 5–75). Food allergy (FA), atopic dermatitis (AD), allergic rhinitis (AR) and allergic conjunctivitis (AC), were defined from a self-completed questionnaire.

August 10, 2022

Dupilumab Drug Survival and Associated Predictors in Patients With Moderate to Severe Atopic Dermatitis

Key Points

Question  What is the drug survival of dupilumab in patients with atopic dermatitis (AD), and what are its associated predictors?

Findings  A total of 715 patients with AD were included with a 1-, 2-, and 3-year overall dupilumab drug survival of 90.3%, 85.9%, and 78.6%, respectively. Patients using immunosuppressive drugs at baseline and nonresponders at week 4 tended to discontinue treatment owing to ineffectiveness more frequently; using immunosuppressive drugs at baseline, older age, and very severe AD were risk factors for shorter drug survival associated with adverse effects.

August 8, 2022

Therapeutic effects elicited by the probiotic Lacticaseibacillus rhamnosus GG in children with atopic dermatitis. The results of the ProPAD trial

Carucci, LNocerino, RPaparo, L, et al. Therapeutic effects elicited by the probiotic Lacticaseibacillus rhamnosus GG in children with atopic dermatitis. The results of the ProPAD trialPediatr Allergy Immunol202233:e13836. doi: 10.1111/pai.13836

Abstract

Background

Atopic dermatitis (AD) is a chronic inflammatory skin disease affecting up to 20% of the pediatric population associated with alteration of skin and gut microbiome. Probiotics have been proposed for AD treatment. The ProPAD study aimed to investigate the therapeutic effects of the probiotic Lacticaseibacillus rhamnosus GG (LGG) in children with AD.

Methods

In total, 100 AD patients aged 6–36 months were enrolled in a randomized, double-blind, controlled trial to receive placebo (Group A) or LGG (1 x 1010 CFU/daily) (Group B) for 12 weeks.

August 5, 2022

A Meta Analysis of Physical Exercise on Improving Lung Function and Quality of Life Among Asthma Patients

 

Qiaoyu Zhu,1 Jianming Zhu,2 Xing Wang,3 Qiong Xu4

1School of Physical Education, Shanghai University, Shanghai, 200444, People’s Republic of China; 2Sports Department, East China University of Political Science and Law, Shanghai, 200042, People’s Republic of China; 3School of Kinesiology, Shanghai University of Sport, Shanghai, 200438, People’s Republic of China; 4School of Physical Health, Shanghai Business School, Shanghai, 201400, People’s Republic of China

J Asthma Allergy. 2022 Jul 13;15:939-955. doi: 10.2147/JAA.S369811.

Objective: This paper aims to perform a systematic assessment of the influence of physical exercise on asthma patients and discuss the intervention effects of different exercises on the lung function FEV1 (%pred) and quality of life among asthma patients so as to lay a scientific foundation for improving asthma symptoms.

Methods: Both Chinese and English databases were retrieved, including PubMed, Web of Science, Embase, The Cochrane Library, CBM, CNKI, Wan Fang Data, and VIP, whose retrieval period started from the founding date of each database to 1st, November 2021. Randomized controlled trials (RCT) studying the symptom indicators of asthma patients were collected.

August 4, 2022

Patient preferences for atopic dermatitis medications in the UK, France and Spain: a discrete choice experiment

Caitlin Thomas, Afaf Raibouaa, Andreas Wollenberg, Jean-Philippe Capron, Nicolas Krucien, Hayley Karn

BMJ Open. 2022 Aug 2;12(8):e058799. doi: 10.1136/bmjopen-2021-058799.

Abstract

Objectives We aimed to quantify patient preferences for efficacy, safety and convenience features of atopic dermatitis (AD) treatments.

Design and setting Online discrete choice experiment survey.

Participants Adults in the UK, France and Spain who had used AD treatments during the past 2 years.

Primary and secondary outcome measures Preferences for attributes were analysed using a multinomial logit model. Willingness to make trade-offs was expressed as the maximum acceptable decrease (MAD) in the probability of achieving clear/almost clear skin at week 16.

Results The survey was completed by 404 patients (44.1±12.0 years; 65% women; 64% moderate/severe eczema).

August 2, 2022

Transient and durable T cell reactivity after COVID-19

Anna Martner , Hanna Grauers Wiktorin , Andreas Törnell  +5 , Johan Ringlander, Mohammad Arabpour, Magnus Lindh, Martin Lagging, Staffan Nilsson, and Kristoffer Hellstrand







Abstract

This study analyzed whole blood samples (n = 56) retrieved from 30 patients at 1 to 21 (median 9) mo after verified COVID-19 to determine the polarity and duration of antigen-specific T cell reactivity against severe acute respiratory syndrome coronavirus 2–derived antigens. Multimeric peptides spanning the entire nucleocapsid protein triggered strikingly synchronous formation of interleukin (IL)-4, IL-12, IL-13, and IL-17 ex vivo until ∼70 d after confirmed infection, whereafter this reactivity was no longer inducible. In contrast, levels of nucleocapsid-induced IL-2 and interferon-γ remained stable and highly correlated at 3 to 21 mo after infection. Similar cytokine dynamics were observed in unvaccinated, convalescent patients using whole-blood samples stimulated with peptides spanning the N-terminal portion of the spike 1 protein.