February 3, 2023

Nonepisodic angioedema with eosinophilia after COVID-19 vaccination: a case successfully treated with reslizumab

  • Case report
  • Open Access


Allergy, Asthma & Clinical Immunology
 volume 19, Article number: 11 (2023

January 31, 2023

Simulation-based education to improve management of refractory anaphylaxis in an allergy clinic

Research - Open Access

Ana M. Copaescu, Francois Graham, Nathalie Nadon, Rémi Gagnon, Arnaud Robitaille, Mohamed Badawy, David Claveau, Anne Des Roches, Jean Paradis, Matthieu Vincent & Philippe Bégin . Allergy, Asthma & Clinical Immunology volume 19, Article number: 9 (2023)


Abstract

Background

High-fidelity simulations based on real-life clinical scenarios have frequently been used to improve patient care, knowledge and teamwork in the acute care setting. Still, they are seldom included in the allergy-immunology curriculum or continuous medical education. Our main goal was to assess if critical care simulations in allergy improved performance in the clinical setting.

Methods

Advanced anaphylaxis scenarios were designed by a panel of emergency, intensive care unit, anesthesiology and allergy-immunology specialists and then adapted for the adult allergy clinic setting. This simulation activity included a first part in the high-fidelity simulation-training laboratory and a second at the adult allergy clinic involving actors and a high-fidelity mannequin.

Allergy: Mechanistic insights into new methods of prevention and therapy

Akdis CA, Akdis M, Boyd SD, Sampath V, Galli SJ, Nadeau KC. 
Allergy: Mechanistic insights into new methods of prevention and therapy. Sci Transl Med. 2023 Jan 18;15(679):eadd2563. doi: 10.1126/scitranslmed.add2563

Abstract
In the past few decades, the prevalence of allergic diseases has increased worldwide. Here, we review the etiology and pathophysiology of allergic diseases, including the role of the epithelial barrier, the immune system, climate change, and pollutants. Our current understanding of the roles of early life and infancy; diverse diet; skin, respiratory, and gut barriers; and microbiome in building immune tolerance to common environmental allergens has led to changes in prevention guidelines.

January 26, 2023

Airway and parenchyma transcriptomics in a house dust mite model of experimental asthma

  • Research
  • Open Access

Lung transcriptomics studies in asthma have provided valuable information in the whole lung context, however, deciphering the individual contributions of the airway and parenchyma in disease pathogenesis may expedite the development of novel targeted treatment strategies. In this study, we performed transcriptomics on the airway and parenchyma using a house dust mite (HDM)-induced model of experimental asthma that replicates key features of the human disease. HDM exposure increased the expression of 3,255 genes, of which 212 were uniquely increased in the airways, 856 uniquely increased in the parenchyma, and 2187 commonly increased in both compartments.

January 25, 2023

Health-related quality of life decreases in young people with asthma during the transition from adolescence to young adulthood: a birth cohort study

Research - Open Access

Maria Ödling, Niklas Andersson, Christer Janson, Erik Melén, Anna Bergström & Inger Kull 


BMC Pulmonary Medicine volume 23, Article number: 34 (2023)

Abstract

Background

During the transition from paediatric to adult healthcare there is a gap between asthma guidelines and actual management with decreased healthcare consultations and dispensations of asthma medications after the transition to adult healthcare among young people with asthma. How health-related quality of life (HRQoL) develops during the transition from adolescence to young adulthood is unclear. Our aim was therefore to investigate HRQoL among young people with asthma during the transition to adulthood. Further, to assess if level of asthma control and physical activity influence any potential association between asthma and HRQoL.

January 21, 2023

Allergen immunotherapy for atopic dermatitis: Systematic review and meta-analysis of benefits and harms

J Allergy Clin Immunol. 2023 Jan;151(1):147-158. doi: 10.1016/j.jaci.2022.09.020.


Abstract
Background: Atopic dermatitis (AD, eczema) is driven by a combination of skin barrier defects, immune dysregulation, and extrinsic stimuli such as allergens, irritants, and microbes. The role of environmental allergens (aeroallergens) in triggering AD remains unclear.
Objective: We systematically synthesized evidence regarding the benefits and harms of allergen immunotherapy (AIT) for AD.

January 19, 2023

Cow’s milk allergy skin tests: fresh milk, commercial extracts, or both?

  • Research
  • Open Access

Abstract

Background

The diagnosis of food allergy is based on a history of immediate allergic reaction following food ingestion, and skin prick test (SPT) demonstrating sensitization with commercial extracts (CE) or fresh food (FF). For most food allergens, the SPT with FF is considered more accurate and predictive. Regarding cow’s milk, the results are inconclusive. This retrospective study aimed to evaluate the accuracy of SPT with fresh milk compared to CE (cow’s milk and casein) for evaluation of cow’s milk allergy (CMA).

January 18, 2023

Treatment with pollen allergen immunotherapy improves health-related quality of life in children and adolescents: a three-year follow-up-study

  • Research
  • Open Access

Abstract

Background

The immunological effect of allergen-specific immunotherapy is well documented, but few studies have examined the long-term effects of pollen subcutaneous immunotherapy (SCIT) on health-related quality of life (HRQoL) in children and adolescents. Therefore, the aims of this study were to evaluate the effect of pollen SCIT on HRQoL and to assess the association between HRQoL and symptoms among children and adolescents with allergic rhinoconjunctivitis in a 3-year follow-up.