Phenotypes of persistent hen`s egg allergy in children and adolescents

Hilal Ünsal 1 ,Sevda Tüten Dal 1 ,Ayşegül Akarsu 1 ,Ümit Murat Şahiner 1 ,Özge Soyer 1 ,Bülent Enis Şekerel 1

1 Division of Pediatric Allergy, Hacettepe University Faculty of Medicine, Ankara, Türkiye

DOI : 10.24953/turkjped.2021.5417

Background. Optimum management of food allergy (FA) includes consideration of co-allergies and multimorbidities and tolerance assessment. Documentation of FA practices may pave the way for better practice.

Methods. Patients aged 3-18 years, with persistent IgE-mediated hen`s egg allergy were reviewed.

Results. A total of 102 children with a median age of 59 months (IQR= 40-84) (72.2% males) were included. All were diagnosed during infancy and the initial symptoms were atopic dermatitis (65.6%), urticaria (18.6%), and anaphylaxis (5.9%).

Asthma occurrence in children and early life systemic antibiotic use: an incidence density study

• Research
• Open Access
• 
  

• Hayat Bentouhami, 
• Milcah Kahkelam Bungwa, 
• Lidia Casas, 
• Samuel Coenen & 
• Joost Weyler 

Allergy, Asthma & Clinical Immunology volume 19, Article number: 18 (2023) 

Abstract

Background

Results of studies evaluating the relationship between asthma occurrence and early life antibiotic use have been conflicting. The aim of this study was to investigate the relationship between occurrence of asthma in children and systemic antibiotic use in the first year of life based on an incidence density study with careful consideration of the temporal aspects of the determinant-outcome relationship.

Methods

We conducted an incidence density study nested in a data collection project with information on 1128 mother–child pairs. Systemic antibiotic use in the first year of life was defined as excessive (≥ 4 courses) vs. non-excessive (< 4 courses) use based on information from weekly diaries.

IgE sensitization to Blo t 21 and Blo t 5 is associated with asthma in the tropics: a case-control study

Zakzuk J1, Donado K1, Mondol E1, Marrugo V1, Regino R1, López JF1, Hernández K1, Mercado D1, Dennis R2, Puerta L1, Caraballo L1

1Institute for Immunological Research, University of Cartagena, Cartagena, Colombia
2Fundación Cardioinfantil, Bogotá, Colombia

J Investig Allergol Clin Immunol 2024; Vol. 34(3) doi: 10.18176/jiaci.0892

Abstract

Background: Blomia tropicalis sensitization is associated with asthma in different tropical and sub-tropical countries; however, information about the specific molecular components associated with this disease is scarce.
Objective: Using molecular diagnosis, we sought to identify B. tropicalis allergens associated with asthma in Colombia.
Methods: Specific IgE (sIgE) to eight B. tropicalis recombinant allergens (Blo t 2/5/7/8/10/12/13 and 21) was determined using an in-house developed ELISA system in asthmatic patients (n=272) and control subjects (n=298) recruited in a national prevalencestudy performed in Colombian cities (Barranquilla, Bogotá, Medellín, Cali and San Andrés). Sample study included children and adults (mean age: 28±SD 17 years old). Cross-reactivity between Blot 5 and Blo t 21 was evaluated by ELISA-inhibition.

Exhaled biomarkers in adults with non-productive cough

• Correspondence
• Open Access
• 
  

• Össur Ingi Emilsson, 
• Spela Kokelj, 
• Jörgen Östling & 
• Anna-Carin Olin 

Respiratory Research volume 24, Article number: 65 (2023) 

Abstract

Background

Chronic cough is a common condition but disease mechanisms are not fully understood. Our aim was to study respiratory biomarkers from the small airways in individuals with non-productive cough.

Methods

A cohort of 107 participants answered detailed questionnaires, performed spirometry, exhaled NO measurement, impulse oscillometry, gave blood samples and particles in exhaled air (PEx) samples. Current smokers (N = 38) were excluded. A total of 14 participants reported non-productive cough (cases).

Molecular Aspects of Allergen-Specific Immunotherapy in Patients with Seasonal Allergic Rhinitis

Open AccessSystematic Review

by 

Marina Izmailovich

 1,*,

Yuliya Semenova

 2,

Gulzada Abdushukurova

 3,

Ainur Mukhamejanova

 4,

Azhar Dyussupova

 5,

Raida Faizova

 5,

Meruert Gazaliyeva

 6,

Leila Akhvlediani

 7,

Natalya Glushkova

 8,

Sundetgali Kalmakhanov

 9 and

Geir Bjørklund

 10

Cells 2023, 12(3), 383; https://doi.org/10.3390/cells12030383

Abstract

A systematic review and narrative synthesis of publications was undertaken to analyze the role of component-resolved diagnosis technology in identifying polysensitization for the provision of allergen-specific immunotherapy to patients with seasonal allergic rhinitis. A search of publications was carried out in electronic databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The search helped to identify 568 publications, 12 of which were included in this review. Overall, 3302 patients were enrolled. The major finding was that component-resolved diagnostics change the choice of relevant allergens for allergen-specific immunotherapy in at least 50% of cases. Sensitization to allergen components differs with age, type of disease, and overall disease duration. Patients who had both bronchial asthma and allergic rhinitis were sensitized to a larger number of allergens than patients who had bronchial asthma alone.

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The Role of Nasal Cytology and Serum Atopic Biomarkers in Paediatric Rhinitis

Open AccessArticle

by 

Giulia Dodi

 1,*,

Paola Di Filippo

 1,

Francesca Ciarelli

 1,

Annamaria Porreca

 2,

Fiorella Cazzato

 3,

Lorena Matonti

 1,

Sabrina Di Pillo

 1,

Giampiero Neri

 3,

Francesco Chiarelli

 1 and

Marina Attanasi

 1

Diagnostics 2023, 13(3), 555; https://doi.org/10.3390/diagnostics13030555

(This article belongs to the Section Clinical Laboratory Medicine)

Abstract

A Nasal Provocation Test allows the differentiation of allergic and non-allergic rhinitis, but it is difficult and expensive. Therefore, nasal cytology is taking hold as an alternative. We carried out a cross-sectional study, including 29 patients with persistent rhinitis according to ARIA definition and negative skin prick tests. Nasal symptoms were scored from 0 to 5 using a visual analogue scale, and patients underwent blood tests to investigate blood cell count (particularly eosinophilia and basophilia), to analyze serum total and specific IgE and eosinophil cationic protein (ECP), and to perform nasal cytology.

Antibiotic Allergy De-Labeling: A Pathway against Antibiotic Resistance

Open AccessEditor’s ChoiceReview

by 

Inmaculada Doña

 1,2,†,

Marina Labella

 1,2,†,

Gádor Bogas

 1,2,

Rocío Sáenz de Santa María

 1,2,

María Salas

 1,2,

Adriana Ariza

 1 and

María José Torres

 1,2,3,4,5,*

Antibiotics 2022, 11(8), 1055; https://doi.org/10.3390/antibiotics11081055 

(This article belongs to the Special Issue Combating Antibiotic Resistance with Precision Medicine: The Value of Diagnostic)

Abstract

Antibiotics are one of the most frequently prescribed drugs. Unfortunately, they also are the most common cause for self-reported drug allergy, limiting the use of effective therapies. However, evidence shows that more than 90% of patients labeled as allergic to antibiotics are not allergic. Importantly, the label of antibiotic allergy, whether real or not, constitutes a major public health problem as it directly impacts antimicrobial stewardship: it has been associated with broad-spectrum antibiotic use, often resulting in the emergence of bacterial resistance. Therefore, an accurate diagnosis is crucial for de-labeling patients who claim to be allergic but are not really allergic. This review presents allergy methods for achieving successful antibiotic allergy de-labeling.

The hen and the egg question in atopic dermatitis: allergy or eczema comes first

• Review
• Open Access
• 
  

• Anastasiia Allenova & 
• Razvigor Darlenski 

Asthma Research and Practice volume 9, Article number: 1 (2023) 

Abstract

Atopic dermatitis (AD) as a chronic inflammatory systemic condition is far more than skin deep. Co-morbidities such as asthma and allergic rhinitis as well as the psychological impact influence seriously the quality of life of the patients. Recent studies have shown that only 10% of atopic patients undergo full manifestation of the atopic march, while 40% demonstrate concomitant food allergy. Exposure to food allergens in the environment causes sensitization and food allergy through the disruption of the skin barrier, as in AD. Food allergy and AD are closely related. While not all AD patients have a food allergy, 20–40% of children with moderate to severe AD will have an IgE-mediated food allergy.