Abstract
KEY POINTS
Abstract
KEY POINTS
Key Points
Question: Does maternal intake of hen’s eggs at birth affect the risk of immunoglobulin E–mediated egg allergy in infants aged 12 months?
Findings: In this randomized clinical trial involving 380 breastfed infants whose parents had an allergic disease, maternal consumption of 1 whole egg per day during the first 5 days after delivery did not affect egg allergy development and sensitization to egg white in the infants compared with complete egg avoidance by the mothers during the same period. No adverse effects were observed.
Meaning: The findings of this randomized clinical trial indicate that egg allergy development is unaffected by maternal egg consumption during the very early neonatal period.
Abstract
Importance: Egg introduction in infants at age 4 to 6 months is associated with a lower risk of immunoglobulin E–mediated egg allergy (EA). However, whether their risk of EA at age 12 months is affected by maternal intake of eggs at birth is unknown.
Abstract
Context: While oral immunotherapy (OIT) has been shown to promote the remission of mild peanut allergy in young children, there is still an unmet need for a disease-modifying intervention for older patients and those with severe diseases. In mice models, abatacept, a cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) immunoglobulin fusion protein, has been shown to promote immune tolerance to food when used as an adjuvant to allergen immunotherapy. The goal of this study is to explore the potential efficacy of abatacept in promoting immune tolerance to food allergens during OIT in humans.
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| ATARI study design. |
Allergy to supplemental lactase is sparsely reported in the literature with only one prior case of anaphylaxis documented [2]. Reactions to this agent can occur following cow’s milk ingestion which could lead to an erroneous diagnosis of cow’s milk allergy in the absence of another explanation.
Our patient, a 48-year-old male with eczema, exercise-induced asthma and rhinoconjunctivitis, presented with four episodes of systemic reactions characterized by mucosal swelling and asthma symptoms following ice-cream exposure.
Abstract
Neutrophils consume a large amount of energy when performing their functions. Compared with other white blood cells, neutrophils contain few mitochondria and mainly rely on glycolysis and gluconeogenesis to produce ATP. The inflammatory site is hypoxic and nutrient poor. Our aim is to study the role of abnormal adenosine metabolism of neutrophils in the asthmatic airway inflammation microenvironment.
In this study, an asthma model was established by intratracheal instillation of Aspergillus fumigatus extract in Ecto-5'-Nucleotidase (CD73) gene–knockout and wild-type mice.
Jiang J, Warren CM, Brewer A, Soffer G, Gupta RS.
Question What is the national distribution of food allergies among all US individuals across race, ethnicity, and socioeconomic groups?
Findings In this survey study of 51 819 households, Asian, Black, and Hispanic individuals were more likely to report having food allergies compared with White individuals. The prevalence of food allergies was lowest among households in the highest income bracket.
Meaning This study suggests that racial, ethnic, and socioeconomic differences in the prevalence of food allergies exist and are evident in clinical outcomes such as food allergy–related emergency department visits and epinephrine autoinjector use.
Importance Food allergies affect approximately 8% of children and 11% of adults in the US. Racial differences in food allergy outcomes have previously been explored among Black and White children, but little is known about the distribution of food allergies across other racial, ethnic, and socioeconomic subpopulations.
Background: Subcutaneous immunotherapy (SCIT) has been proved to be effective and safe in adult asthma. But it is still controversial in children.
Object: To evaluate the efficacy and safety of SCIT in asthmatic children with allergy to house dust mite.
Chen Zheng
Zhimin Chen