Systemic inflammatory proteins in offspring following maternal probiotic supplementation for atopic dermatitis prevention

Zakiudin, D.P., Rø, A.D.B., Videm, V. et al. Clin Mol Allergy 21, 5 (2023)

Abstract

Background

Maternal probiotic supplementation has a promising effect on atopic dermatitis (AD) prevention in infancy. In the randomised controlled study, Probiotics in the Prevention of Allergy among Children in Trondheim (ProPACT), maternal probiotics reduced the cumulative incidence of AD in their offspring by 40% at 2 years of age. However, our understanding on how probiotics prevented AD is still limited, and the role of inflammatory proteins in infants following maternal probiotic supplementation is unclear. We hypothesised that maternal probiotics lowered pro-inflammatory proteins and increased anti-inflammatory proteins in their 2-year-old children as a mechanism of AD prevention. We aimed to explore this hypothesis and the association between these proteins and the presence of AD, severity of AD, and the degree of preventive effect of probiotics.

Acute and Chronic Urticaria Diagnosis and Management Taking into Account Their Differences

Salman, A., Porras, N.M. & Gimenez-Arnau, A.M. Curr Treat Options Allergy 10, 130–147 (2023). https://doi.org/10.1007/s40521-023-00333-w

Abstract

Purpose of review

Urticaria is a frequent disorder that can present with erythema, edema, and pruritus involving the skin and mucous membranes. Early diagnosis and proper management of the urticaria according to the type (i.e., acute vs chronic) is of utmost importance to reduce the burden of the disease and prevent psychosocial comorbidities. In this review, we aim to summarize the diagnosis and management of acute and chronic urticaria with emphasis on the differences.

Recent findings

Autoimmune mechanisms (type I or type IIb autoimmunity) have been recently defined in the pathogenesis of chronic spontaneous urticaria. Despite the high rates of symptom control in both acute and chronic urticaria with the existing treatment options, new treatments are still needed in a subset of patients.

Advances in understanding of the pathogenesis and therapeutic implications of drug reaction with eosinophilia and systemic symptoms: an updated review

Chen CB, Hung WK, Wang CW, Lee CC, Hung SI, Chung WH.  Front Med (Lausanne). 2023 Jun 29;10:1187937. doi: 10.3389/fmed.2023.1187937. 

Abstract

 Pathogenesis of DRESS/DIHS.

Drug reaction with eosinophilia and systemic symptoms or drug-induced hypersensitivity syndrome (DRESS/DIHS) is one type of severe cutaneous adverse reaction (SCAR). It is featured by fever, widespread skin lesions, protracted clinical course, internal organ involvement, and possibly long-term autoimmune sequelae. The presence of high-risk human leukocyte antigen (HLA) alleles, hypersensitivity reaction after culprit drug ingestion, and human herpesvirus reactivation may all contribute to its complex clinical manifestations.

Clinical characteristics and treatment outcomes of severe asthma patients with a history of multiple biologic drugs use

Free article

Tomohiro Akaba, Mitsuko Kondo, Soshi Muramatsu, Kazuhiro Abe, Fumi Kobayashi, Azusa Miyoshi, Osamitsu Yagi, Kiyoshi Takeyama, Etsuko Tagaya

Asian Pac J Allergy Immunol. 2023 Jun;41(2):106-112. doi: 10.12932/AP-170221-1070.

Abstract

Background: Asthma control has been shown to improve after clinical use of molecular-targeted biologic drugs. Although most patients have shown favorable responses to biologic drugs, some individuals need to switch to another biologic drug. To date, limited data are available regarding patients who received multiple biologic drugs.

Objective: We aimed to evaluate the characteristics and outcomes of patients treated with multiple biologic drugs.

Methods: We reviewed severe asthma patients who received biologic drugs between May 2009 and September 2019. Clinical characteristics of patients and changes in annualized asthma exacerbation rates, asthma control test (ACT), and oral corticosteroid (OCS) dose, before and after the use of the final biologic drug, were evaluated.

Therapy resistant urticaria as a long-term symptom of an incomplete Schnitzler syndrome

• Case report
• Open Access

• Viktoria Puxkandl, 
• Antonia Currie, 
• Wolfram Hoetzenecker & 
• Sabine Altrichter 

Allergy, Asthma & Clinical Immunology volume 19, Article number: 64 (2023) 

Abstract

Background

Recurring therapy resistant hives, accompanied by IgM-gammopathy, fever and joint pain can indicate Schnitzler syndrome, a rare autoimmune disorder. There is currently no approved treatment, but complete remission of symptoms can be induced with IL-1 antagonists.

Case presentation

A patient with a history of chronic urticaria presented frequently at the outpatient clinic with severe hives and was treated unsuccessfully with antihistamines and omalizumab. After several years, additional symptoms such as joint pain, recurrent fever, and IgM-gammopathy developed. After the diagnostic criteria for Schnitzler syndrome were met, treatment with anakinra was initiated and resulted in an improvement of the symptoms.

3D Bioprinting—A Model for Skin Aging

Ryeim B Ansaf, Rachel Ziebart, Hemanth Gudapati, Rafaela Mayumi Simoes Torigoe, Stella Victorelli, Joao Passos, Saranya P Wyles

Regenerative Biomaterials,  https://doi.org/10.1093/rb/rbad060

 

Abstract

Human lifespan continues to extend as an unprecedented number of people reach their seventh and eighth decade of life, unveiling chronic conditions that affect the older adult. Such skin conditions include senile purpura, seborrheic keratoses, pemphigus vulgaris, bullous pemphigoid, diabetic foot wounds, and skin cancer. Current methods of drug testing prior to clinical trials require the use of pre-clinical animal models, which are often unable to adequately replicate human skin response.

Patterns in the Development of Pediatric Allergy

Basophils in pruritic skin diseases

Free PMC article

Wiebe D, Limberg MM, Gray N, Raap U.  Front Immunol. 2023 Jul 3;14:1213138. doi: 10.3389/fimmu.2023.1213138

Abstract

Basophils are rare cells in the peripheral blood which have the capability to infiltrate into the skin. Invasion of basophils has been detected in pruritic skin diseases, including atopic dermatitis, bullous pemphigoid, chronic spontaneous urticaria and contact dermatitis. In the skin, basophils are important players of the inflammatory immune response, as they release Th2 cytokines, including interleukin (IL)-4 and IL-13, subsequently inducing the early activation of T-cells.