Acquired Non-histaminergic Angioedema With C1q Autoantibody and Urticaria: A Case Report

Kochvar A P, Cobb G, Bernabe C C, et al. Cureus 15(8): e43841. doi:10.7759/cureus.43841

Abstract

Acquired angioedema (AAE) is a rare disease with life-threatening complications. This pathology has classically been associated with medication use and B cell lymphoproliferative disorders. In this report, we describe a 61-year-old man with a six-year history of angioedema, unrelated to any known triggers or malignancy. Extensive workup has led to a diagnosis of idiopathic nonhistaminergic AAE with normal C1 inhibitor. The patient is currently being treated with lanadelumab, which has resolved the patient’s symptoms. This case provides insight into the onset, exploration, treatment, and outcomes of an extremely rare disease process.

PDF

Drug Allergy in Children: Adverse Reactions after Skin Testing

Karavaizoglu C, Suleyman A, Yavuz Alıc R et al. Int Arch Allergy Immunol. 2023 Sep 20:1-7. doi: 10.1159/000533641.

Abstract

Introduction: Skin tests are one of the most widely used diagnostic tools for suspected drug allergies in children. Studies on systemic reactions occurring during skin testing with allergens have mostly been conducted in pediatric and adult patient groups together. However, data on adverse reactions including allergic reactions after drug skin tests in children are scarce. It is aimed to determine the adverse reactions after skin test in children with suspected drug allergy. 

Guideline for allergological diagnosis of drug hypersensitivity reactions: S2k Guideline of the German Society for Allergology and Clinical Immunology (DGAKI) in cooperation with the German Dermatological Society (DDG), the Association of German Allergologists (ÄDA), the German Society for Pediatric Allergology (GPA), the German Contact Dermatitis Research Group (DKG), the German Society for Pneumology (DGP), the German Society of Otorhinolaryngology, Head and Neck Surgery, the Austrian Society of Allergology and Immunology (ÖGAI), the Austrian Society of Dermatology and Venereology (ÖGDV), the German Academy of Allergology and Environmental Medicine (DAAU), and the German Documentation Center for Severe Skin Reactions (dZh)

Brockow K, Wurpts G, Trautmann A et al.   Allergol Select. 2023 Aug 9;7:122-139. doi: 10.5414/ALX02422E.

Abstract

Not available.

• PDF (1.2M)

Efficacy of Biologics in Patients with Allergic Severe Asthma, Overall and by Blood Eosinophil Count: A Literature Review

Bernstein JA, Llanos JP, Hunter G, Martin N, Ambrose CS.  Adv Ther. 2023 Sep 12. doi: 10.1007/s12325-023-02647-2. 

Abstract

Patients with uncontrolled, allergic severe asthma may be prescribed biologic therapies to reduce exacerbations and improve disease control. Randomized controlled trials (RCTs) of these therapies have differed in design, with varying results overall and by baseline blood eosinophil count (BEC). This study describes published annualized asthma exacerbation rate (AAER) reductions from RCTs in patients with allergic severe asthma, overall and by baseline BEC category. A literature search was performed to identify published phase 3 RCT data of US Food and Drug Administration-approved biologics for severe asthma in patients with severe, uncontrolled asthma and confirmed sensitization to perennial aeroallergens.

Novel, computational IgE-clustering in a population-based cross-sectional study: Mapping the allergy burden

Czolk, R, Ruiz-Castell, M, Hunewald, O, et al. Clin Transl Allergy. 2023;e12292. https://doi.org/10.1002/clt2.12292 Open Access.

Abstract

Background

Even though the prevalence of allergies is increasing, population-based data are still scarce. As a read-out for chronic inflammatory information, new methods are needed to integrate individual biological measurements and lifestyle parameters to mitigate the consequences and costs of allergic burden for society.

Methods

More than 480.000 data points were collected from 1462 Luxembourg adults during the representative, cross-sectional European Health Examination Survey, spanning health and lifestyle reports.

Mendelian randomization analysis to analyze the genetic causality between different levels of obesity and different allergic diseases

Yujian Li & 

Xuan Kan 

BMC Pulmonary Medicine volume 23, Article number: 352 (2023) 

• details

Abstract

Background

The causal relationship between obesity and different allergic diseases remains controversial.

Methods

The Two Sample MR package and Phenoscanner database were used to obtain and filter Genome-Wide Association Study (GWAS) data from the Open GWAS database. Mendelian randomization (MR) analysis was used to study the causal relationship between different levels of obesity and different allergic diseases. The data sets related to obesity and asthma were obtained from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were screened by the limma package. Cluster Profiler and GO plot packages were used for enrichment analysis to verify the results of MR analysis.

Airway inflammatory changes in the lungs of patients with asthma-COPD overlap (ACO): a bronchoscopy endobronchial biopsy study

• Surajit Dey, 
• Wenying Lu, 
• Greg Haug, 
• Collin Chia, 
• Josie Larby, 
• Heinrich C. Weber, 
• Archana Vijay Gaikwad, 
• Prem Bhattarai, 
• Affan Mahmood Shahzad, 
• Prabuddha S. Pathinayake, 
• Peter A. B. Wark, 
• Mathew Suji Eapen & 
• Sukhwinder Singh Sohal 

Respiratory Research volume 24, Article number: 221 (2023) 

• details

Representation of antibody-positive cells that were counted in the epithelial,
reticular basement membrane (RBM), and lamina propria (LP) areas

Abstract

Background

Although asthma and chronic obstructive pulmonary disease (COPD) are two distinct chronic airway inflammatory diseases, they often co-exist in a patient and the condition is referred to as asthma-COPD overlap (ACO). Lack of evidence regarding the inflammatory cells in ACO airways has led to their poor prognosis and treatment. The objective of this endobronchial biopsy (EBB) study was to enumerate inflammatory cellular changes in the airway wall of ACO compared with asthma, COPD current smokers (CS) and ex-smokers (ES), normal lung function smokers (NLFS), and non-smoker controls (HC).

Methods

EBB tissues from 74 patients were immunohistochemically stained for macrophages, mast cells, eosinophils, neutrophils, CD8+ T-cells and CD4+ T-cells.

Using the AllerSearch Smartphone App to Assess the Association Between Dry Eye and Hay Fever: mHealth-Based Cross-Sectional Study

Inomata T, Sung J, Nakamura M et al. J Med Internet Res. 2023 Sep 12;25:e38481. doi: 10.2196/38481.

Abstract

Background: Dry eye (DE) and hay fever (HF) show synergistic exacerbation of each other’s pathology through inflammatory pathways.

Objective: This study aimed to investigate the association between DE and HF comorbidity and the related risk factors.

Methods: A cross-sectional observational study was conducted using crowdsourced multidimensional data from individuals who downloaded the AllerSearch smartphone app in Japan between February 2018 and May 2020. AllerSearch collected the demographics, medical history, lifestyle and residential information, HF status, DE symptoms, and HF-related quality of life. HF symptoms were evaluated using the nasal symptom score (0-15 points) and nonnasal symptom score (0-12 points).