INTRODUCTION
January 13, 2024
Unsafe medications for patients with food allergy
Airway disease decreases the therapeutic potential of epithelial stem cells
Abstract
Backgorund
Tissue-engineered tracheal grafts (TETG) can be recellularized by the host or pre-seeded with host-derived cells. However, the impact of airway disease on the recellularization process is unknown.
Methods
In this study, we determined if airway disease alters the regenerative potential of the human tracheobronchial epithelium (hTBE) obtained by brushing the tracheal mucosa during clinically-indicated bronchoscopy from 48 pediatric and six adult patients.
Results
Our findings revealed that basal cell recovery and frequency did not vary by age or region. At passage 1, all samples produced enough cells to cellularize a 3.5 by 0.5 cm2 graft scaffold at low cell density (~ 7000 cells/cm2), and 43.75% could cellularize a scaffold at high cell density (~ 100,000 cells/cm2).
January 12, 2024
CRUSE®—An innovative mobile application for patient monitoring and management in chronic spontaneous urticaria
Abstract
Background
Chronic spontaneous urticaria (CSU) is unpredictable and can severely impair patients' quality of life. Patients with CSU need a convenient, user-friendly platform to complete patient-reported outcome measures (PROMs) on their mobile devices. CRUSE®, the Chronic Urticaria Self Evaluation app, aims to address this unmet need.
Methods
CRUSE® was developed by an international steering committee of urticaria specialists. Priorities for the app based on recent findings in CSU were defined to allow patients to track and record their symptoms and medication use over time and send photographs. The CRUSE® app collects patient data such as age, sex, disease onset, triggers, medication, and CSU characteristics that can be sent securely to physicians, providing real-time insights. Additionally, CRUSE® contains PROMs to assess disease activity and control, which are individualised to patient profiles and clinical manifestations.
January 11, 2024
Understanding progression from pre-school wheezing to school-age asthma: Can modern data approaches help?
Abstract
Preschool wheezing and childhood asthma create a heavy disease burden which is only exacerbated by the complexity of the conditions. Preschool wheezing exhibits both “curricular” and “aetiological” heterogeneity: that is, heterogeneity across patients both in the time-course of its development and in its underpinning pathological mechanisms. Since these are not fully understood, but clinical presentations across patients may nonetheless be similar, current diagnostic labels are imprecise—not mapping cleanly onto underlying disease mechanisms—and prognoses uncertain. These uncertainties also make a identifying new targets for therapeutic intervention difficult. In the past few decades, carefully designed birth cohort studies have collected “big data” on a large scale, incorporating not only a wealth of longitudinal clinical data, but also detailed information from modalities as varied as imaging, multiomics, and blood biomarkers.
January 8, 2024
Telehealth Expansion, Internet Speed, and Primary Care Access Before and During COVID-19
Key Points
Question What disparities emerged in access to primary care telehealth services during the COVID-19 pandemic, and to what degree is access to high-speed internet associated with disparities in telehealth utilization?
Findings In this cohort study of 172 387 Wisconsin Medicaid beneficiaries, telehealth expansion exposed disparities in utilization of telehealth services that persisted even among beneficiaries with high-speed internet.
Meaning These findings suggest that expansion of telehealth service or access to high-speed internet is unlikely to close gaps in utilization of primary care services.
Abstract
Importance Primary care (PC) receipt is associated with better health outcomes. How telehealth expansion and internet speed are associated with PC use is unclear.
California's early transition to electric vehicles: Observed health and air quality co-benefits
Garcia E, Johnston J, McConnell R, Palinkas L, Eckel SP. Sci Total Environ. 2023 Apr 1;867:161761. doi: 10.1016/j.scitotenv.2023.161761.
Abstract
The transition to electric vehicles is projected to have considerable public health co-benefits, but most evidence regarding air quality and health impacts comes from projections rather than real-world data. We evaluated whether population-level respiratory health and air quality co-benefits were already detectable at the relatively low levels of zero-emissions vehicles (ZEVs: battery electric, plug-in hybrid, hydrogen fuel cell vehicle) adoption in California, and evaluated the ZEV adoption gap in underserved communities.
January 7, 2024
Gut microbiota facilitate chronic spontaneous urticaria
Zhu L, Jian X, Zhou B, Liu R, Muñoz M, Sun W, Xie L, Chen X, Peng C, Maurer M, Li J. Nat Commun. 2024 Jan 2;15(1):112. doi: 10.1038/s41467-023-44373-x. Abstract
 |
| CSU comes with reduced gut microbiome diversity |
January 6, 2024
Usefulness of Drug Allergy Alert Systems: Present and Future
Abstract
Purpose of Review
The goal of this paper is to review drug allergy alert systems (DAAS), to summarise their key components, and to overview potential benefits and challenges associated with these tools. Methods for validation of their effects on patient safety, alternative uses, and strategies to streamline DAAS’ functions and reduce system fatigue are discussed.
Recent Findings
DAAS are clinical decision support systems (CDSS) that focus on preventing drug adverse events within healthcare settings. The advent of electronic medical records has facilitated the development of digital DAAS. Existing versions use different methods to document diagnosed allergies, and rely on distinct rules and matching strategies for the generation of real-time alerts. 
Understanding the functionality of drug allergy alert systems.
Subscribe to:
Posts (Atom)