Urticaria as a dermatologic manifestation of Giardia infection: a systematic review of clinical, diagnostic, and therapeutic features

Mahdavi, J., Ahmadifar, K. & Ghasemikhah, R. BMC Infect Dis 25, 1085 (2025). https://doi.org/10.1186/s12879-025-11484-3

Abstract

Background

Giardiasis is recognized as the most prevalent enteric protozoal infection worldwide. Although gastrointestinal symptoms are the most common manifestations of giardiasis, several studies have reported cases of urticaria associated with this infection. Urticaria is a common mast cell-dependent disorder characterized by wheals, angioedema, or both. The aim of this study was to conduct the first systematic review to comprehensively synthesize the clinical, diagnostic, and therapeutic features of urticaria as a dermatologic manifestation in patients with giardiasis.

Methods

This review was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement. PubMed/MEDLINE, Web of Science, Scopus, ScienceDirect, and Google Scholar were searched without language restrictions up to 2025 to identify articles reporting patients with urticaria and giardiasis.

Results

Number of cases from different countries

Thirteen papers describing a total of 23 patients (14 males and 9 females, aged 4 to 56 years) were included. The locations of urticarial lesions varied, involving the head, trunk, and extremities. The duration of urticaria ranged from 8 h to 8 months.

Prevention of Atopic Dermatitis in High-Risk Infants: A Review of the Role of Lipid-Based Barrier Repair Therapy

C.-W. J. Chan and M. O. Visscher,  Pediatric Dermatology (2025): 1–14, https://doi.org/10.1111/pde.70010.

ABSTRACT

Background/Objective

Growing evidence highlights the role of physiological lipids, namely ceramides, cholesterol, and free fatty acids, in maintaining skin barrier function and preventing atopic dermatitis (AD). Current evidence on the efficacy, safety, and clinical relevance of stratum corneum (SC) lipid-based therapies to prevent AD and increase skin barrier integrity in high-risk infants was reviewed and synthesized.

Methods

Searches with key words lipid-based therapy, atopic dermatitis, infant, and prevention were conducted to identify papers using PubMed, Embase, Cochrane Library, and Scopus databases from January 2000 to June 2024.

Results

SC lipid-based therapies were reported to replenish deficient SC lipids, thereby improving skin barrier function, a critical aspect of AD management.

Broad-spectrum synthetic carbohydrate receptors (SCRs) inhibit viral entry across multiple virus families

Ezzatpour S, Thakur K, Erzoah Ndede K et al.  Sci Adv. 2025 Aug 29;11(35):eady3554. doi: 10.1126/sciadv.ady3554. Epub 2025 Aug 27. 

Abstract

Viral pandemics continue to threaten global health and economic stability. Despite medical advances, the absence of broad-spectrum antivirals (BSAs) prevents rapid responses to emerging viral threats. This is largely due to the lack of universal drug targets across diverse viral families and high variability among viral proteins. In this study, we evaluated 57 synthetic carbohydrate receptors (SCRs) for antiviral activity in cellulo using pseudotyped virus particles (PVPs) from six high-risk viruses across three families: Paramyxoviridae, Filoviridae, and Coronaviridae. 

Binding of SCRs to N-glycan microarrays

Four SCRs inhibited all tested PVPs, and their efficacy was confirmed against live viruses including SARS-CoV-2, MERS-CoV, EBOV, MARV, NiV, and HeV.

Early-life allergic sensitization and respiratory infection—Two hits on lung function?

Wadhwa V, Dharmage SC, Wurzel D, et al. Pediatr Allergy Immunol. 2025; 36:e70115. doi:10.1111/pai.70115

Abstract

Background

Allergic sensitization and respiratory infections commonly occur in childhood. Interplay between them in asthma development is known as the ‘two-hit’ hypothesis. There has been no previous investigation of this hypothesis on adult lung function.

Objective

In a birth cohort at high risk for allergic diseases, we investigated interactions between these two factors and lung function outcomes into adulthood.

Methods

Allergic sensitization was assessed at age 24 months by skin prick testing to aero and food allergens. Respiratory infection was defined as cough, rattle or wheeze measured by frequent questionnaires up to age 24 months. Regression models were utilized to identify interactions between these exposures and associations with lung function at ages 12, 18 and 25 years.

Results

Association between respiratory infection (increasing number of
months) and allergic sensitization with change in lung function
z-scores (post-bronchodilator)—sensitization status at 2 years.

At age 25 years, those sensitized at age 2 years(n = 118) demonstrated reductions in pre-bronchodilator FEV1 of 0.06(95% CI: −0.12, 0.00, z-score units, p = .055) for each additional month of respiratory infections.

RSV Vaccine Effectiveness Against Hospitalization Among US Adults Aged 60 Years or Older During 2 Seasons

Surie D, Self WH, Yuengling KA, et al. . JAMA. Published online August 30, 2025. doi:10.1001/jama.2025.15896

Key Points

Question  What is the effectiveness of 1 dose of respiratory syncytial virus (RSV) vaccine against RSV-associated hospitalization among adults aged 60 years or older during 2 RSV seasons and by time since vaccination?

Findings  In this multicenter, test-negative, case-control study of 6958 adults with RSV, estimated RSV vaccine effectiveness against RSV-associated hospitalization during 2 seasons was 58%. Vaccine effectiveness was 69% when vaccination occurred in the same season before illness onset and 48% when vaccination occurred in the prior season; these estimates were not statistically significantly different.

Validation and Acceptability of the Mobile App Version of the Control of Allergic Rhinitis and Asthma Test for Children (CARATKids): Cross-Sectional Study

Abreu da Mata D, Pais-Cunha I, Ferraz SC, da Rocha Couto D, Ferraz C, Silva S, Valente JC, Vieira-Marques P, A Fonseca J, Azevedo I, Jácome C.  JMIR Pediatr Parent. 2025 Jul 31;8:e73531. doi: 10.2196/73531. 

Abstract

Background: The electronic version of the Control of Allergic Rhinitis and Asthma Test for Children (CARATKids) has the potential to enhance pediatric telemonitoring but has not yet been validated.

Objective: This study aimed to validate the electronic version of CARATKids against the paper-based version.

Methods: A cross-sectional study was conducted between April and December 2024 in a tertiary hospital in northern Portugal. Children with asthma or allergic rhinitis and their caregivers were recruited during pulmonology outpatient appointments.

The role of complement in long COVID pathogenesis

Bayarri-Olmos R, Bain W, Iwasaki A.  JCI Insight. 2025 Aug 22;10(16):e194314. doi: 10.1172/jci.insight.194314.

Abstract

Proposed drivers of complement activation in long COVID

Long COVID is a debilitating condition that can develop after a SARS-CoV-2 infection and is characterized by a wide range of chronic symptoms, including weakness, neurocognitive impairment, malaise, fatigue, and many others, that affect multiple organ systems. At least 10% of individuals with a previous infection may develop long COVID, which affects their ability to perform daily functions and work.

Distinct trajectories of childhood atopic dermatitis are associated with differences in long-term inflammatory and cardiometabolic disease risks

Florian Thaçi, Philip Curman, Katja Bieber, Henning Olbrich, Diamant Thaçi, Ralf J. Ludwig

medRxiv 2025.08.18.25333898; doi: https://doi.org/10.1101/2025.08.18.25333898

This article is a preprint and has not been certified by peer review. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.

Abstract

Importance Atopic dermatitis (AD) is a common childhood inflammatory skin disease which occurs frequently in the early childhood and is later linked to type 2 diseases but also other systemic comorbidities. The role of different AD-disease trajectories on long-term health outcomes remains unclear, as prior studies have rarely conducted direct comparisons between distinct AD trajectories.

Objective To assess how different childhood AD trajectories - persistent, transient - or none, are associated with long-term risks of other type 2 inflammatory diseases (T2IDs), autoimmune diseases, and cardiometabolic disorders by performing all pairwise comparisons to identify trajectory-specific risk patterns.