Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1β

Research

Peng Gao¹²³, Peter G Gibson²³⁴, Katherine J Baines²³, Ian A Yang⁵⁶, John W Upham⁵⁷,Paul N Reynolds⁸⁹, Sandra Hodge⁸⁹, Alan L James¹⁰¹¹, Christine Jenkins¹², Matthew J Peters¹³¹⁴, Jie Zhang¹ and Jodie L Simpson^23*

Abstract

Background

Galectin-3 (gal-3), a member of the β-galactoside-binding animal lectins, is involved in the recruitment, activation and removal of neutrophils. Neutrophilic asthma is characterized by a persistent elevation of airway neutrophils and impaired efferocytosis. We hypothesized that sputum gal-3 would be reduced in neutrophilic asthma and the expression of gal-3 would be associated with other markers of neutrophilic inflammation.

The need for patient-focused therapy for children and teenagers with allergic rhinitis: a case-based review of current European practice

Review

Alexandra F Santos¹²³, Luis Miguel Borrego⁴⁵, Giuseppina Rotiroti⁶, Glenis Scadding⁶ andGraham Roberts^10789*

Clinical and Translational Allergy 2015, 5:2  doi:10.1186/s13601-014-0044-5

Abstract

Allergic rhinitis is a common problem in childhood and adolescence, with a negative impact on the quality of life of patients and their families.

Clinical validation of controlled grass pollen challenge in the Environmental Exposure Unit (EEU)

Research

Anne K Ellis^12*, Lisa M Steacy², Barnaby Hobsbawn², Caroline E Conway² and Terry JB Walker²

Allergy, Asthma & Clinical Immunology 2015, 11:5  doi:10.1186/s13223-015-0071-3

Published: 27 January 2015

Abstract

Rationale

The Environmental Exposure Unit (EEU), a controlled allergen exposure model of allergic rhinitis (AR), has traditionally utilized ragweed pollen. We sought to clinically validate the use of grass pollen in the EEU.

Anaphylaxis due to caffeine

	Case Report  Open Access
	Asia Pac Allergy. 2015 Jan;5(1):55-56. English. Published online Jan 28, 2015.  http://dx.doi.org/10.5415/apallergy.2015.5.1.55  Copyright © 2015. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. Kumiya Sugiyama,1,2 Tatsurai Cho,3 Masamitsu Tatewaki,1,2 Shogo Onishi,2 Tatsuya Yokoyama,2 Naruo Yoshida,1,2 Takayoshi Fujimatsu,1,2 Hirokuni Hirata,2 Takeshi Fukuda,2 and Yasutsugu Fukushima1,2 1Department of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya 343-8555, Japan. 2Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Mibu 321-0293, Japan. 3Moka-Seibu Clinic, Moka 321-4364, Japan.

Idiopathic hypereosinophilic syndrome: a rare cause of erythroderma

• J Dermatol Case Rep
• v.8(4); 2014 Dec 31
• PMC4299705

J Dermatol Case Rep. 2014 Dec 31; 8(4): 108–114.

Published online 2014 Dec 31. doi:  10.3315/jdcr.2014.1185

PMCID: PMC4299705

Vikram K. Mahajan,1,* Ravinder Singh,1 Karaninder S. Mehta,1 Pushpinder S. Chauhan,1 Saurabh Sharma,2 Mrinal Gupta,1 and Ritu Rawat1

Author information ► Article notes ► Copyright and License information ►

Abstract

Background

Idiopathic hypereosinophilic syndrome (HES) is a rare and potentially lethal disorder characterized by persistently elevated eosinophil counts without any underlying causes.

The value of spirometry and exercise challenge test to diagnose and monitor children with asthma

Respirology Case Reports

Early View (Online Version of Record published before inclusion in an issue)

1. Lara S. van den Wijngaart^*, 
2. Jolt Roukema and
3. Peter J.F.M. Merkus

Article first published online: 3 FEB 2015

DOI: 10.1002/rcr2.92

Abstract

Asthma is defined as a chronic inflammatory disease of the airways with characteristic symptoms including recurrent episodes of wheezing, breathlessness, chest tightness, and coughing.

Respiratory disease and respiratory physiology: Putting lung function into perspective: Paediatric asthma

Invited Review Series: Respiratory Disease: Using Lung Function Measurements to Greater Advantage

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Lara S. van den Wijngaart^*, 

Jolt Roukema and

Peter J.F.M. Merkus

Article first published online: 3 FEB 2015 DOI: 10.1111/resp.12480

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Abstract

Dealing with paediatric asthma in daily practice, we are mostly interested in the airway function: the hallmark of asthma is the variability of airway patency.

Influence of the route of exposure and the matrix on the sensitization potency of a major cows’ milk allergen

Brief communication

Published: 28 January 2015

Sophie Wavrin¹, Herve Bernard¹, Jean-Michel Wal² and Karine Adel-Patient^1*

Clinical and Translational Allergy 2015, 5:3  doi:10.1186/s13601-015-0047-x

Abstract (provisional)

Background

Allergic sensitisation to food may occur through non-gastrointestinal routes such as via skin or lung. We recently demonstrated in mice that cutaneous or respiratory pre-exposures to peanut proteins on intact epithelia induce a Th2 priming and allow subsequent oral sensitization without the use of adjuvant. We then aimed to assess the impact of a similar pattern of exposure to another relevant food allergen, cows´ milk.