Obesity Increases Airway Hyperresponsiveness via the TNF-α Pathway and Treating Obesity Induces Recovery

PLoS One. 2015 Feb 6;10(2):e0116540. doi: 10.1371/journal.pone.0116540. eCollection 2015.

Kim JY1, Sohn JH2, Lee JH2, Park JW2.

Author information

Abstract

Obesity is a known risk factor for allergic asthma. It has been recognized as a key player in the pathogenesis of several inflammatory disorders via activation of macrophages, which is also vital to the development of allergic asthma. We investigated the mechanism of obesity-related asthma and whether treating obesity through exercise or diet ameliorates the severity of asthma in the obesity-related asthma model.

A randomised dose-ranging study of tiotropium Respimat ® in children with symptomatic asthma despite inhaled corticosteroids

Research

Published: 7 February 2015

Christian Vogelberg^1*, Petra Moroni-Zentgraf², Migle Leonaviciute-Klimantaviciene³, Ralf Sigmund⁴, Eckard Hamelmann⁵, Michael Engel² and Stanley Szefler⁶

Respiratory Research 2015, 16:20  doi:10.1186/s12931-015-0175-9

Abstract (provisional)

Background 

A considerable number of children with asthma remain symptomatic despite treatment with inhaled corticosteroids, resulting in significant morbidity, reduced quality of life, increased healthcare costs and lost school days. The aim of our study was to assess the efficacy, safety and tolerability of once-daily tiotropium Respimat 5µg, 2.5µg and 1.25µg add-on to medium-dose inhaled corticosteroids, with or without a leukotriene modifier, in children aged 6-11 years with symptomatic asthma.

Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1β

Research

Peng Gao¹²³, Peter G Gibson²³⁴, Katherine J Baines²³, Ian A Yang⁵⁶, John W Upham⁵⁷,Paul N Reynolds⁸⁹, Sandra Hodge⁸⁹, Alan L James¹⁰¹¹, Christine Jenkins¹², Matthew J Peters¹³¹⁴, Jie Zhang¹ and Jodie L Simpson^23*

Abstract

Background

Galectin-3 (gal-3), a member of the β-galactoside-binding animal lectins, is involved in the recruitment, activation and removal of neutrophils. Neutrophilic asthma is characterized by a persistent elevation of airway neutrophils and impaired efferocytosis. We hypothesized that sputum gal-3 would be reduced in neutrophilic asthma and the expression of gal-3 would be associated with other markers of neutrophilic inflammation.

The need for patient-focused therapy for children and teenagers with allergic rhinitis: a case-based review of current European practice

Review

Alexandra F Santos¹²³, Luis Miguel Borrego⁴⁵, Giuseppina Rotiroti⁶, Glenis Scadding⁶ andGraham Roberts^10789*

Clinical and Translational Allergy 2015, 5:2  doi:10.1186/s13601-014-0044-5

Abstract

Allergic rhinitis is a common problem in childhood and adolescence, with a negative impact on the quality of life of patients and their families.

Clinical validation of controlled grass pollen challenge in the Environmental Exposure Unit (EEU)

Research

Anne K Ellis^12*, Lisa M Steacy², Barnaby Hobsbawn², Caroline E Conway² and Terry JB Walker²

Allergy, Asthma & Clinical Immunology 2015, 11:5  doi:10.1186/s13223-015-0071-3

Published: 27 January 2015

Abstract

Rationale

The Environmental Exposure Unit (EEU), a controlled allergen exposure model of allergic rhinitis (AR), has traditionally utilized ragweed pollen. We sought to clinically validate the use of grass pollen in the EEU.

Anaphylaxis due to caffeine

	Case Report  Open Access
	Asia Pac Allergy. 2015 Jan;5(1):55-56. English. Published online Jan 28, 2015.  http://dx.doi.org/10.5415/apallergy.2015.5.1.55  Copyright © 2015. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. Kumiya Sugiyama,1,2 Tatsurai Cho,3 Masamitsu Tatewaki,1,2 Shogo Onishi,2 Tatsuya Yokoyama,2 Naruo Yoshida,1,2 Takayoshi Fujimatsu,1,2 Hirokuni Hirata,2 Takeshi Fukuda,2 and Yasutsugu Fukushima1,2 1Department of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya 343-8555, Japan. 2Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Mibu 321-0293, Japan. 3Moka-Seibu Clinic, Moka 321-4364, Japan.

Idiopathic hypereosinophilic syndrome: a rare cause of erythroderma

• J Dermatol Case Rep
• v.8(4); 2014 Dec 31
• PMC4299705

J Dermatol Case Rep. 2014 Dec 31; 8(4): 108–114.

Published online 2014 Dec 31. doi:  10.3315/jdcr.2014.1185

PMCID: PMC4299705

Vikram K. Mahajan,1,* Ravinder Singh,1 Karaninder S. Mehta,1 Pushpinder S. Chauhan,1 Saurabh Sharma,2 Mrinal Gupta,1 and Ritu Rawat1

Author information ► Article notes ► Copyright and License information ►

Abstract

Background

Idiopathic hypereosinophilic syndrome (HES) is a rare and potentially lethal disorder characterized by persistently elevated eosinophil counts without any underlying causes.

The value of spirometry and exercise challenge test to diagnose and monitor children with asthma

Respirology Case Reports

Early View (Online Version of Record published before inclusion in an issue)

1. Lara S. van den Wijngaart^*, 
2. Jolt Roukema and
3. Peter J.F.M. Merkus

Article first published online: 3 FEB 2015

DOI: 10.1002/rcr2.92

Abstract

Asthma is defined as a chronic inflammatory disease of the airways with characteristic symptoms including recurrent episodes of wheezing, breathlessness, chest tightness, and coughing.