Abstract (provisional)
A blog that publishes updates and open access scientific papers about allergy, asthma and immunology. Editor: Juan Carlos Ivancevich, MD. Specialist in Allergy & Immunology
February 25, 2015
A randomised dose-ranging study of tiotropium Respimat® in children with symptomatic asthma despite inhaled corticosteroids
Research
Christian Vogelberg1*, Petra Moroni-Zentgraf2, Migle Leonaviciute-Klimantaviciene3, Ralf Sigmund4, Eckard Hamelmann5, Michael Engel2 and Stanley Szefler6
Abstract
Background
A considerable number of children with asthma remain symptomatic despite treatment with inhaled corticosteroids, resulting in significant morbidity, reduced quality of life, increased healthcare costs and lost school days.
February 24, 2015
Insights and advances in chronic urticaria: a Canadian perspective
Review
Gordon Sussman1*, Jacques Hébert2, Wayne Gulliver3, Charles Lynde1, Susan Waserman4, Amin Kanani5, Moshe Ben-Shoshan6, Spencer Horemans1, Carly Barron1,Stephen Betschel1, William H Yang7, Jan Dutz5, Neil Shear1, Gina Lacuesta8, Peter Vadas1, Kenneth Kobayashi7, Hermenio Lima4 and F Estelle R Simons9
Abstract
In the past few years there have been significant advances which have changed the face of chronic urticaria. In this review, we aim to update physicians about clinically relevant advances in the classification, diagnosis and management of chronic urticaria that have occurred in recent years.
Effects of Nasal Corticosteroids on Boosts of Systemic Allergen-Specific IgE Production Induced by Nasal Allergen Exposure
OPEN ACCESS
PEER-REVIEWED
RESEARCH ARTICLE
Cornelia Egger, Christian Lupinek, Robin Ristl, Patrick Lemell, Friedrich Horak, Petra Zieglmayer, Susanne Spitzauer, Rudolf Valenta, Verena Niederberger
Published: February 23, 2015
Abstract
Background
Allergen exposure via the respiratory tract and in particular via the nasal mucosa boosts systemic allergen-specific IgE production. Intranasal corticosteroids (INCS) represent a first line treatment of allergic rhinitis but their effects on this boost of allergen-specific IgE production are unclear.
February 23, 2015
Sleepiness, inflammation and oxidative stress markers in middle-aged males with obstructive sleep apnea without metabolic syndrome: a cross-sectional study
Research
Daniela Kuguimoto Andaku1, Vânia D’Almeida14*, Gláucia Carneiro2, Sônia Hix13, Sergio Tufik1 and Sônia Maria Togeiro1
Published: 14 January 2015
Abstract
Background
The simultaneous occurrence of metabolic syndrome and excessive daytime sleepiness are very common in obstructive sleep apnea (OSA) patients. Both conditions, if present in OSA, have been reported to be associated with inflammation and disruption of oxidative stress balance that impair the cardiovascular system. To verify the impact of daytime sleepiness on inflammatory and oxidative stress markers, we evaluated OSA patients without significant metabolic disturbance.
February 22, 2015
The development of a standardised diet history tool to support the diagnosis of food allergy
The disparity between reported and diagnosed food allergy makes robust diagnosis imperative.
February 20, 2015
No evidence for altered intracellular calcium-handling in airway smooth muscle cells from human subjects with asthma
Research article
David Sweeney12†, Fay Hollins1†, Edith Gomez12, Rajendra Mistry2, Ruth Saunders1,Robert Alfred John Challiss2* and Christopher Edward Brightling1*
David Sweeney and Fay Hollins contributed equally to this work.
Published: 13 February 2015
Abstract (provisional)
Background
Asthma is characterized by airway hyper-responsiveness and variable airflow obstruction, in part as a consequence of hyper-contractile airway smooth muscle, which persists in primary cell culture. One potential mechanism for this hyper-contractility is abnormal intracellular Ca2+ handling.
February 17, 2015
Vitamin D deficiency in pregnancy and its impact on the fetus, the newborn and in childhood
- Open Access funded by Sociedade de Pediatria de São Paulo
- Under a Creative Commons license
Abstract
Objective
Vitamin D deficiency (VDD) in pregnant women and their children is an important health problem with severe consequences for the health of both. Thus, the objectives of this review were to reassess the magnitude and consequences of VDD during pregnancy, lactation and infancy, associated risk factors, prevention methods, and to explore epigenetic mechanisms in early fetal life capable of explaining many of the non‐skeletal benefits of vitamin D (ViD).
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