Allergen inhalation challenge, refractoriness and the effects of ibuprofen

RESEARCH

 

OPEN ACCESS

• Shawn Nomani,
• Donald W. Cockcroft and
• Beth E. DavisEmail author

Allergy, Asthma & Clinical Immunology201612:24

DOI: 10.1186/s13223-016-0127-z

Abstract

Background

Bronchoprovocation challenges use direct or indirect acting stimuli to induce airflow obstruction. Indirect stimuli either non-allergic/non-IgE mediated (e.g. exercise, mannitol) or allergic/IgE mediated (i.e. allergen) trigger mast cells to release bronchoconstricting mediators (e.g. cysteinyl leukotrienes, histamine). Performing repeat challenges within a short timeframe (e.g. 3 h) with non-allergic indirect stimuli results in a diminished, refractory response to the second challenge that is inhibited by non-steroidal anti-inflammatory medications. Cross refractoriness occurs between indirect stimuli.

LINX®, a novel treatment for patients with refractory asthma complicated by gastroesophageal reflux disease: a case report

CASE REPORT

 

OPEN ACCESS

• Narin SriratanaviriyakulEmail author,
• Celeste Kivler,
• Tamas J. Vidovszky,
• Ken Y. Yoneda,
• Nicholas J. Kenyon,
• Susan Murin and
• Samuel Louie

Journal of Medical Case Reports201610:124

DOI: 10.1186/s13256-016-0887-6

Open Peer Review reports

Abstract

Background

Gastroesophageal reflux disease is one of the most common comorbidities in patients with asthma. Gastroesophageal reflux disease can be linked to difficult-to-control asthma. Current management includes gastric acid suppression therapy and surgical antireflux procedures. The LINX® procedure is a novel surgical treatment for patients with gastroesophageal reflux disease refractory to medical therapy.

Financial Relationships between Organizations That Produce Clinical Practice Guidelines and the Biomedical Industry: A Cross-Sectional Study

• Paul Campsall,
• Kate Colizza,
• Sharon Straus,
• Henry T. Stelfox

http://dx.doi.org/10.1371/journal.pmed.1002029

Abstract

Background

Financial relationships between organizations that produce clinical practice guidelines and biomedical companies are vulnerable to conflicts of interest. We sought to determine whether organizations that produce clinical practice guidelines have financial relationships with biomedical companies and whether there are associations between organizations’ conflict of interest policies and recommendations and disclosures provided in guidelines.

Microbiome and its Impact on Gastrointestinal Atopy

Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

DOI: 10.1111/all.12943

Amanda B. Muir^1,2,*, 

Alain J. Benitez³,

Kara Dods¹, 

Jonathan M. Spergel^2,3and

Sophie A. Fillon⁴

• Abstract

Abstract

The prevalence of allergic conditions has continuously increased in the last few decades in Westernized countries. A dysbiotic gut microbiome may play an important role in the development of allergic diseases. Genetic, environmental and dietary factors may alter the commensal microbiota leading to inflammatory dysregulation of homeostasis. Murine and human studies have begun to elucidate the role of the microbiota in the pathogenesis of atopic diseases including asthma, atopic dermatitis and food allergies. However, the role of the microbiome in most eosinophilic gastrointestinal diseases (EGIDs) is not yet known. This review provides an overview of what is currently known about the development of tolerance from both molecular and clinical standpoints. We also look at the gut specific microbiome and its role in atopic conditions with the hope of applying this knowledge to the understanding, prevention and treatment of EGIDs, particularly EoE.

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Periostin - A Novel Systemic Biomarker for Eosinophilic Airway Inflammation: A Case Control Study

•  Clin Diagn Res
• v.10(2); 2016 Feb
• PMC4800558

J Clin Diagn Res. 2016 Feb; 10(2): OC01–OC04.

Published online 2016 Feb 1. doi:  10.7860/JCDR/2016/14553.7166

PMCID: PMC4800558

Viswanathan Emprm,1 MG Rajanandh,2 and AD Nageswari3

Author information ► Article notes ► Copyright and License information ►

Abstract

Introduction

Chronic airway inflammation and remodelling are fundamental features of asthma. The molecular phenotypes in asthma are Th2 high and Th2 low. Serum periostin is a biomarker which aid in understanding Th2 high eosinophilic asthma.

Aim

The present study aimed to identify whether or not serum periostin is a systemic biomarker for eosinophilic airway inflammation in asthmatics.

Updosing of nonsedating anti-histamines in recalcitrant chronic urticaria

REVIEW ARTICLE

Year : 2016  |  Volume : 61  |  Issue : 3  |  Page : 273-278

Kiran Godse, Prachi Bhattar, Sharmila Patil, Nitin Nadkarni, Manjyot GautamDepartment of Dermatology, Dr. D. Y. Patil Medical College and Hospital, Nerul, Navi Mumbai, Maharashtra, India Abstract   Chronic urticaria (CU) is a persistent, debilitating condition that causes severe impairment on the quality of life (QoL) of patient by interrupting work productivity. Current guidelines recommend second-generation (nonsedating) anti-histamines for the treatment for all forms of urticaria. In patients who do not respond adequately to conventional doses of anti-histamines, it is recommended to increase the dose to up to four times to obtain control. But there are only few controlled studies that have assessed the efficacy and safety of nonsedating anti-histamines.

Occupational and environmental risk factors for chronic rhinosinusitis in China: a multicentre cross-sectional study

Respiratory Research201617:54

DOI: 10.1186/s12931-016-0366-z

Wen-Xiang Gao, Chun-Quan Ou, Shu-Bin Fang, Yue-Qi Sun, Hua Zhang, Lei Cheng, Yan-Jun Wang, Dong-Dong Zhu, Wei Lv, Shi-Xi Liu, P. Z. Li, Geng Xu, Jianbo Shi and Qing-Ling Fu

Background

Chronic rhinosinusitis (CRS) is defined as a condition of inflammation in the paranasal sinus mucosa persisting for more than 12 weeks. We previously reported that the prevalence of CRS was about 8 % in China. Here, we aim to investigate the occupational and environmental risk factors associated with CRS.

How relevant is panallergen sensitisation in the development of allergies?

Pediatric Allergy and Immunology

Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

• Abstract
• Cited By

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Abstract

Panallergens comprise various protein families of plant as well as animal origin and are responsible for wide IgE cross-reactivity between related and unrelated allergenic sources.