Acute eosinophilic pneumonia related to a mesalazine suppository

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Case Report  Open Access

|    Asia Pac Allergy. 2013 Apr;3(2):136-139. English. Published online 2013 April 26.  http://dx.doi.org/10.5415/apallergy.2013.3.2.136  Copyright © 2013. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. Acute eosinophilic pneumonia related to a mesalazine suppository Jung Hyun Kim,1 June-Hyuk Lee,1 Eun-Suk Koh,2 Sung woo Park,1 An-Soo Jang,1 Dojin Kim,1 and Choon-Sik Park1 1Division of Respiratory and Allergy, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon 420-767, Korea. 2Department of Pathology, Soonchunhyang University Bucheon Hospital, Bucheon 420-767, Korea.  Correspondence: June-Hyuk Lee. Division of Respiratory and Allergy, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, 170, jomaru-ro, Wonmi-gu, Bucheon 420-767, Korea. Tel: +82-32-621-5154, Fax: +82-32-621-6950, Email: junehyuk@schmc.ac.kr  Received July 25, 2012; Accepted February 24, 2013. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract It has been well known that mesalazine can cause the interstitial lung disease, such as Bronchiolitis obliterans with organizing pneumonia (BOOP), Non-Specific Interstitial Pneumonia (NSIP), or eosinophilic pneumonia. 5-Aminosalicylic acid (5-ASA), mesalazine, and sulfasalazine are important drugs for treating inflammatory bowel disease. Topical products of these limited systemic absorption and have less frequent side effects, therefore suppository form of these drugs have been used more than systemic drug. Most cases of measalzine-induced lung toxicity develop from systemic use of the drug. A 30-year-old woman had an interstitial lung disease after using mesalazine suppository because of ulcerative colitis. The lung biopsy demonstrated eosinophilic pneumonia combined with BOOP. She was recovered after stopping of mesalazine suppository and treatment with systemic steroid. Keywords: Eosinophilic pneumonia, Bronchiolitis obliterans with organizing pneumonia, Mesalazine, Suppository. Full Text