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| Staphylococcal enterotoxin specific IgE and asthma: a systematic review and meta-analysis |
Woo-Jung Song,1,2 Eun-Jung Jo,3 Ji-Won Lee,1,2 Hye-Ryun Kang,1,2 Sang-Heon Cho,1,2 Kyung-Up Min,1,2 andYoon-Seok Chang 1,2,4 |
| 1Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea. |
| 2Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul 110-799, Korea. |
| 3Department of Internal Medicine, Pusan National University College of Medicine, Busan 602-739, Korea. |
| 4Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam 463-707, Korea. |
Correspondence: Yoon-Seok Chang. Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam 463-707, Korea. Tel: +82-31-787-7023, Fax: +82-31-787-4052, Email: addchang@snu.ac.kr
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Received March 19, 2013; Accepted March 22, 2013.
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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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| Abstract |
Background
Recent literature suggests that Staphylococcal enterotoxin specific IgE may be a risk factor for asthma.
Objective
To investigate the associations between Staphylococcal enterotoxin sensitization and asthma.
Methods
A systematic review and meta-analysis was performed for relevant case-control or population-based studies, published in the peer-reviewed journals until February 2013. Data were extracted on study designs, subjects, definitions and the prevalence of Staphylococcal enterotoxin sensitization.
Results
A total of 683 studies were initially identified, of which 7 studies finally met the inclusion criteria (5 case-control and 2 population-based studies). All the included studies reported higher prevalence of the sensitization in asthmatics than in controls, despite clinical and methodological heterogeneity. In a meta-analysis, the pooled odds ratio of the sensitization for asthma was 2.95 (95% confidence intervals 2.28-3.82).
Conclusion
Staphylococcal enterotoxin sensitization was significantly associated with asthma. The mechanisms of associations warrant further elucidation.
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Keywords: Asthma, Staphylococcus, Meta-analysis.
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Open Access
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