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Drug Discov Today Dis Mech. Author manuscript; available in PMC 2013 December 11.

Published in final edited form as:

Drug Discov Today Dis Mech. 2012 December 1; 9(3-4): 10.1016/j.ddmec.2012.09.003.

Published online 2012 October 18. doi:  10.1016/j.ddmec.2012.09.003

PMCID: PMC3859144

NIHMSID: NIHMS411529

TSLP: A Key Regulator of Asthma Pathogenesis

Erin E. West, Mohit Kashyap, and Warren J. Leonard*

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Abstract

Asthma is a complex disorder of the airways that is characterized by T helper type 2 (Th2) inflammation. The pleiotrophic cytokine TSLP has emerged as an important player involved in orchestrating the inflammation seen in asthma and other atopic diseases. Early research elucidated the role of TSLP on CD4+ T cells, and recent work has revealed the impact of TSLP on multiple cell types. Furthermore, TSLP plays an important role in the sequential progression of atopic dermatitis to asthma, clarifying the key role of TSLP in the pathogenesis of asthma, a finding with therapeutic implications.

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Abstract

Asthma is a complex disorder of the airways that is characterized by T helper type 2 (Th2) inflammation. The pleiotrophic cytokine TSLP has emerged as an important player involved in orchestrating the inflammation seen in asthma and other atopic diseases. Early research elucidated the role of TSLP on CD4+