Journal of Immunology Research
Volume 2014 (2014), Article ID 780386, 6 pages
http://dx.doi.org/10.1155/2014/780386
Review Article
Laboratory of Dermatology and Immunodeficiencies, LIM-56, Medical School, University of Sao Paulo, Avenida Dr. Eneas de Carvalho Aguiar 500, Third Floor, 05403-000 Sao Paulo, SP, Brazil
Received 16 April 2014; Accepted 30 May 2014; Published 9 June 2014
Academic Editor: Kurt Blaser
Copyright © 2014 Jefferson Russo Victor. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
A variety of mechanisms are involved in the regulation of offspring allergy development through maternal immunization with allergens. The passive transfer of antigens, antibodies, and cytokines, the induction of phenotypic alterations in offspring lymphocytes, and the induction of regulatory populations in offspring have been proposed, but these mechanisms remain incompletely understood. It is likely that maternal immunization could affect the intrathymic maturation of offspring TCD4+, TCD8+, T, nTreg, iNKT, and B lymphocytes, although there are currently no human maternal immunization protocols for the regulation of allergic responses in children. Some studies have suggested a direct interaction between the maternal immune status and the offspring intrathymic microenvironment; this interaction could influence the maturation of offspring regulatory cells and must be explored for the development of therapies to control allergy development in children.
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