Vitamin D deficiency and interleukin-17 relationship in severe obstructive sleep apnea–hypopnea syndrome

ORIGINAL ARTICLE

Year : 2017  |  Volume : 12  |  Issue : 2  |  Page : 107-113

Sonia Toujani1, Wajih Kaabachi2, Meriem Mjid1, Kamel Hamzaoui2, Jouda Cherif1, Majed Beji1 1 Department of Basic Sciences, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia 2 Unit Research 12SP15 “Homeostasis and Cell Dysfunction”, Abderrahman Mami Hospital, Ariana, Tunisia Correspondence Address: Sonia Toujani Department of Basic Sciences, Faculty of Medicine of Tunis, University of Tunis El Manar Tunisia Check DOI: 10.4103/atm.ATM_301_16

Abstract   Purpose: We aimed to assess Vitamin D (VD) abnormalities in patients with severe obstructive sleep apnea–hypopnea syndrome (OSAHS), to study its association with clinical and polygraphic data, and to correlate VD levels with interleukin-17 (IL-17). Methods: Ninety-two patients with severe OSAHS were consecutively enrolled between September 2014 and February 2016 and compared to age-, sex-, and body mass index (BMI)-matched controls. Anthropometric parameters and medical history were collected. The serum levels of VD and IL-17 were determined by radioimmunoassay and enzyme-linked immunosorbent assay, respectively. Results: Ninety-two severe OSAHS patients and thirty controls were enrolled in the study. All OSAHS patients had VD deficiency. The mean level of VD was at 7.9 ng/ml among OSAHS group versus 16.8 ng/ml among control group. IL-17A levels were elevated (20.3 pg/ml) in OSAHS group compared to healthy group (10.05 pg/ml). VD levels were negatively correlated with nocturia severity (r = −0.26; P = 0.01) and positively correlated with mean O2saturation (r = 0.59; P = 0.02) and lowest O2saturation (r = 0.3; P = 0.03). IL-17 levels were positively correlated with nocturia severity (r = 0.24; P = 0.03) and negatively correlated with mean O2saturation (r = −0.42; P = 0.03). A significant negative association was observed between IL-7 and VD levels (r = −0.64, P = 0.2 10−4). The magnitude of this correlation was higher for important nocturia, lower MSaO2, or higher BMI. Conclusions: VD deficiency in patients with severe OSAHS is common with a negative association between IL-17 and VD serum levels. Hypoxia could play an important role in this association. Further studies are needed to clarify this relationship. Keywords: Inflammation, interleukin-17, obstructive sleep apnea, Vitamin D How to cite this article: Toujani S, Kaabachi W, Mjid M, Hamzaoui K, Cherif J, Beji M. Vitamin D deficiency and interleukin-17 relationship in severe obstructive sleep apnea–hypopnea syndrome. Ann Thorac Med 2017;12:107-13 How to cite this URL: Toujani S, Kaabachi W, Mjid M, Hamzaoui K, Cherif J, Beji M. Vitamin D deficiency and interleukin-17 relationship in severe obstructive sleep apnea–hypopnea syndrome. Ann Thorac Med [serial online] 2017 [cited 2017 Apr 14];12:107-13. Available from: http://www.thoracicmedicine.org/text.asp?2017/12/2/107/203745    Article in PDF (616 KB)