Lupin, a potential "hidden" food anaphylaxis allergen: An alert from the Allergy-Vigilance Network®.

Pouessel G, Sabouraud-Leclerc D, Beaumont P, Divaret-Chauveau A, Bradatan E, Dumond P, Karaca Y, Renaudin JM, Metz-Favre C, Delalande D, Correard AK, Tscheiller S, Van der Brempt X. Allergy. 2024 Mar 22. doi: 10.1111/all.16107.

To the Editor,

Lupin is a legume considered as an emerging food allergen, but the true prevalence of lupin allergy is not known.1 Due to the increasing consumption of lupin and its potential cross-reactivity with peanut, the Allergy-Vigilance Network® (AVN) aimed to report lupin-induced anaphylaxis cases and compare their main characteristics to other foods (See Data S1 for Material and Methods).

Main characteristics of 62 patients with a lupin-induced anaphylaxis
recorded by the Allergy-Vigilance Network® and comparisons by age groups

Of the 2708 cases of food-induced anaphylaxis documented by AVN (2002-2020), 62 (2.3%) cases were induced by lupin and cases are presented by time periods and according to total number of food-induced anaphylaxis cases (Figure S1). The main characteristics of these 62 cases (mean age: 32.1 years [SD: 21.4], 35% in children <18 years, 66% in females) are presented.

Nine (15%) patients had a history of lupin allergy confirmed by an allergist and 4 (6%) a known sensitization to lupin; 22 (35%) patients had a known food allergy (peanut, n = 16). Allergic sensitizations according to foods and families of component-resolved reactivity are presented in the Figure S2. Of the 62 patients, a history of asthma was reported in 14 (23%), and allergic rhinitis in 12 (19%)...

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