Mahjoubi, M., Rashedi, R., Samieefar, N. et al. Allergy Asthma Clin Immunol 21, 20 (2025). https://doi.org/10.1186/s13223-025-00963-6
Abstract
Background
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Generalized erythematous and excoriated papules suggesting an eczematous dermatitis in a 10-year-old boy with HIES |
Methods
This narrative review explores the dermatologic presentations of Hyper-IgE Syndrome in pediatric populations
, including descriptions, associated symptoms/findings, and available treatment options.Results and conclusion
Neonatal rash, mucocutaneous candidiasis, noma neonatorum, psoriasis, cold staphylococcal abscesses, and candida onychomycosis are among the dermatological manifestations of Hyper-IgE Syndrome. Each manifestation has unique characteristics and treatment considerations, necessitating accurate recognition and diagnosis for effective management. Optimal treatment strategies involve a combination of supportive care, topical/systemic therapies, antifungal medications, and surgical interventions when necessary. Further research is needed to enhance our understanding of these manifestations and evaluate treatment modalities for individuals affected by Hyper-IgE Syndrome.
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