May 4, 2025

Dermatologic presentations of hyper IgE syndrome in pediatric patients

Mahjoubi, M., Rashedi, R., Samieefar, N. et al. Allergy Asthma Clin Immunol 21, 20 (2025). https://doi.org/10.1186/s13223-025-00963-6


Abstract

Background

Generalized erythematous and excoriated papules
suggesting an eczematous dermatitis in a
10-year-old boy with HIES
Hyper-IgE Syndrome, also known as Job’s syndrome, is a rare primary immunodeficiency disorder characterized by recurrent infections and elevated levels of immunoglobulin E. While respiratory and systemic manifestations have been more emphasized, dermatological manifestations in Hyper-IgE Syndrome also play a significant role in disease presentation.

Methods

This narrative review explores the dermatologic presentations of Hyper-IgE Syndrome in pediatric populations

, including descriptions, associated symptoms/findings, and available treatment options.

Results and conclusion

Neonatal rash, mucocutaneous candidiasis, noma neonatorum, psoriasis, cold staphylococcal abscesses, and candida onychomycosis are among the dermatological manifestations of Hyper-IgE Syndrome. Each manifestation has unique characteristics and treatment considerations, necessitating accurate recognition and diagnosis for effective management. Optimal treatment strategies involve a combination of supportive care, topical/systemic therapies, antifungal medications, and surgical interventions when necessary. Further research is needed to enhance our understanding of these manifestations and evaluate treatment modalities for individuals affected by Hyper-IgE Syndrome.

PDF


No comments:

Post a Comment