Yu, ZhebinMetspalu, Andres et al. The Lancet Regional Health – Europe, Volume 0, Issue 0, 101314
Summary
Background
The joint impact of exposure to multiple urban environmental factors on asthma remains unclear.
Methods
We analysed data from 14 European cohorts to assess the impact of the urban exposome on asthma incidence across the life course. We linked three external exposome domains (air pollution, built environment, ambient temperature) to the participants’ home addresses at baseline. We performed k-means clustering within each domain and assessed associations of clusters with asthma adjusting for potentially relevant covariates in cohort-specific analyses, with subsequent separate meta-analyses for birth and adult cohorts. An environmental risk score using a coefficient-weighted sum approach was used to assess the impact of combining the three domains.
Findings
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Associations between the environmental risk score (combining three external exposome domains) and asthma incidence |
Interpretation
Multiple environmental exposures jointly contribute to incident asthma risk across the life course. Urban planning accounting for these factors may help mitigate asthma development.
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