Healthy people in healthy premises: the Finnish Indoor Air and Health Programme 2018–2028

• Research
• Open Access
• 
  

• Jussi Lampi, 
• Anne Hyvärinen, 
• Marina Erhola, 
• Tari Haahtela, 
• Kyösti Haukipuro, 
• Ulla Haverinen-Shaughnessy, 
• Kaisa Jalkanen, 
• Kirsi Karvala, 
• Sanna Lappalainen, 
• Kari Reijula, 
• Hannele Rämö, 
• Markku Sainio, 
• Anniina Salmela, 
• Mika Salminen, 
• Tuula Vasankari & 
• Juha Pekkanen 

Clinical and Translational Allergy volume 10, Article number: 4 (2020) 

• details

Abstract

Main focus areas of Finnish Healthy Premises 2028 Programme.
The Finnish Indoor Air and Health Programme implements
and supports these measures (Enhancement of health and well-being)
 and closely collaborates with programme’s other actors

Clean and fresh indoor air supports health and well-being. However, indoor air can contain pollutants that can cause a variety of symptoms and reduce well-being. Individual exposure agents can also increase the risk of certain diseases. Finns have taken major steps to improve the quality of indoor air for several decades. The primary focus of these activities has been the prevention and reduction of exposure to poor indoor air quality through guidance and regulation directing remediation of damaged buildings. Nevertheless, reported symptoms related to poor indoor air quality are common in Finland.

Association between atopic dermatitis and colorectal cancer risk

RESEARCH ARTICLE: OBSERVATIONAL STUDY

A nationwide cohort study

Chou, Wan-Yun MS^a; Lai, Pin-Yu MS^b; Hu, Je-Ming MD^c,d,e; Hsu, Chih-Hsiung MS^c,f; Chen, Yong-Chen PhD^g,h; Tian, Yu-Feng MD^i,j; You, San-Lin PhD^g,h; Hsiao, Cheng-Wen MD^d; Chou, Yu-Ching PhD^a,b,∗; Sun, Chien-An ScD^h,k,∗

Section Editor(s): Kok., Victor C.

 Author Information

Medicine: January 2020 - Volume 99 - Issue 1 - p e18530

doi: 10.1097/MD.0000000000018530

Abstract

The role of atopic dermatitis (AD) in the development of colorectal cancer (CRC) has been a matter of scientific debate with mixed results. We conducted a nationwide cohort study to assess the association between AD and risk of CRC. Drawing on Taiwan's National Health Insurance Research Database, 46,703 patients with AD (the AD cohort) and 186,812 sex, age, and index year-matched patients without AD (the non-AD cohort) were identified in the period between 2000 and 2008.

Clinical Management of Seafood Allergy

January 2020 Volume 8, Issue 1, Pages 37–44

Carla M. Davis, MDa,∗,Correspondence information about the author MD Carla M. DavisEmail the author MD Carla M. Davis

, 

Ruchi S. Gupta, MD, MPHb

, 

Ozge N. Aktas, MDc

, 

Veronica Diaz, MDa

, 

Sandip D. Kamath, PhDd

, 

Andreas L. Lopata, PhDd

Open Access

DOI: https://doi.org/10.1016/j.jaip.2019.10.019

 |

Article Info

Abstract

Seafood plays an important role in human nutrition and health. A good patient workup and sensitive diagnostic analysis of IgE antibody reactivity can distinguish between a true seafood allergy and other adverse reactions generated by toxins or parasites contaminating ingested seafood. The 2 most important seafood groupings include the fish and shellfish.

Use of antibiotics and asthma medication for acute lower respiratory tract infections in people with and without asthma: retrospective cohort study

• Research
• Open Access

• Rachel Denholm, 
• Esther T. van der Werf & 
• Alastair D. Hay 

Respiratory Research volume 21, Article number: 4 (2020) 

• details

Abstract

Background

Antibiotics are overused in patients with acute lower respiratory tract infections (ALRTIs), but less is known about their use in patients with asthma, or the use of asthma medication for ALRTI in patients without asthma. Our aim was to describe the frequency, variation and drivers in antibiotic and asthma medication prescribing for ALRTI in adults with and without asthma in primary care.

Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care

Volume74, Issue12, December 2019, Pages 2293-2311

Heimo Breiteneder  Zuzana Diamant  Thomas Eiwegger  Wytske J. Fokkens  Claudia Traidl‐Hoffmann  Kari Nadeau  Robyn E. O’Hehir  Liam O’Mahony  Oliver Pfaar  Maria J. Torres  De Yun Wang  Luo Zhang  Cezmi A. Akdis 

REVIEW Open Access

Abstract

The specialties of allergy and clinical immunology have entered the era of precision medicine with the stratification of diseases into distinct disease subsets, specific diagnoses, and targeted treatment options, including biologicals and small molecules. 

This article reviews recent developments in research and patient care and future trends in the discipline. The section on basic mechanisms of allergic diseases summarizes the current status and defines research needs in structural biology, type 2 inflammation, immune tolerance, neuroimmune mechanisms, role of the microbiome and diet, environmental factors, and respiratory viral infections. In the section on diagnostic challenges, clinical trials, precision medicine and immune monitoring of allergic diseases, asthma, allergic and nonallergic rhinitis, and new approaches to the diagnosis and treatment of drug hypersensitivity reactions are discussed in further detail.

Perspectives in allergen immunotherapy: 2019 and beyond

First published: 24 December 2019 https://doi.org/10.1111/all.14077

REVIEW ARTICLE - Open Access

Oliver Pfaar  Ioana Agache  Frédéric de Blay  Sergio Bonini  Adam M. Chaker  Stephen R. Durham  Radoslaw Gawlik  Peter W. Hellings  Marek Jutel  Jörg Kleine‐Tebbe  Ludger Klimek  Matthias V. Kopp  Andreas Nandy  Ronald L. Rabin  Ronald van Ree  Harald Renz  Graham Roberts  Anne‐Marie Salapatek  Carsten B. Schmidt‐Weber  Mohamed H. Shamji  Gunter J. Sturm  J. Christian Virchow  Ulrich Wahn  Christoph Willers  Petra Zieglmayer  Cezmi A. Akdis

Abstract

The seventh “Future of the Allergists and Specific Immunotherapy (FASIT)” workshop held in 2019 provided a platform for global experts from academia, allergy clinics, regulatory authorities and industry to review current developments in the field of allergen immunotherapy (AIT). Key domains of the meeting included the following:

Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper

• Review
• Open Access
• Clinical and Translational Allergy

• Valerie Hox, 
• Evelijn Lourijsen, 
• […]
• Philippe Gevaert 

Clinical and Translational Allergy volume 10, Article number: 1 (2020) 

Abstract

Because of the inflammatory mechanisms of most chronic upper airway diseases such as rhinitis and chronic rhinosinusitis, systemic steroids have been used for their treatment for decades. However, it has been very well documented that—potentially severe—side-effects can occur with the accumulation of systemic steroid courses over the years. A consensus document summarizing the benefits of systemic steroids for each upper airway disease type, as well as highlighting the potential harms of this treatment is currently lacking.

Efficacy and Safety of Multiple Dupilumab Dose Regimens After Initial Successful Treatment in Patients With Atopic Dermatitis A Randomized Clinical Trial

Original Investigation

Margitta Worm, MD¹; Eric L. Simpson, MD²; Diamant Thaçi, MD³; et alRobert Bissonnette, MD⁴; Jean-Philippe Lacour, MD⁵; Stefan Beissert, MD⁶; Makoto Kawashima, MD⁷; Carlos Ferrándiz, MD, PhD⁸; Catherine H. Smith, MD⁹; Lisa A. Beck, MD¹⁰; Kuo-Chen Chan, PhD¹¹; Zhen Chen, PhD¹¹; Bolanle Akinlade, MD¹¹; Thomas Hultsch, MD¹²; Heribert Staudinger, MD, PhD¹³; Abhijit Gadkari, PhD¹¹; Laurent Eckert, PhD¹⁴; John D. Davis, PhD¹¹; Manoj Rajadhyaksha, PhD¹¹; Neil M. H. Graham, MB, BS, MD, MPH¹¹; Gianluca Pirozzi, MD, PhD¹³; Neil Stahl, PhD¹¹; George D. Yancopoulos, MD, PhD¹¹; Marius Ardeleanu, MD¹¹

Author Affiliations Article Information

JAMA Dermatol. doi:https://doi.org/10.1001/jamadermatol.2019.3617

Key Points

Question  Do dupilumab regimens less frequent than once weekly or every 2 weeks maintain long-term efficacy and safety?

Findings  In this randomized clinical trial of 422 patients, high-responding patients previously treated for 16 weeks with 300 mg of dupilumab weekly or every 2 weeks who continued those regimens had the most consistent efficacy; patients taking lower-dose regimens (every 4 or 8 weeks) or placebo had a dose-dependent reduction in response and no safety advantage.

Expression of COX-1, COX-2, 5-LOX and CysLT2CysLT2 in nasal polyps and bronchial tissue of patients with aspirin exacerbated airway disease

• Research
• Open Access

Allergy, Asthma & Clinical Immunology

• Monique Vorsprach, 
• Christoph Arens, 
• Stephan Knipping, 
• Dörte Jechorek, 
• Sabine Stegemann-Koniszewski, 
• Eva Lücke & 
• Jens Schreiber 

Allergy, Asthma & Clinical Immunology volume 15, Article number: 83 (2019) 

• details

Abstract

Background

Aspirin exacerbated respiratory disease (AERD) is a disease of the upper and lower airways. It is characterized by severe asthma, chronic sinusitis with nasal polyps (CRSwNP) and intolerance towards nonsteroidal analgesics (NSAR). Arachidonic acid (AA) metabolites play an important role in the pathogenesis of AERD. It is still unknown, whether metabolism of AA is comparable between the upper and lower airways as well as between patients with and without NSAR intolerance.

Early-life exposure to humidifier disinfectant determines the prognosis of lung function in children

• Research article
• Open Access
• Open Peer Review

BMC Pulmonary Medicine

• Hyun-Ju Cho, 
• So Yeon Lee, 
• Donguk Park, 
• Seung-Hun Ryu, 
• Jisun Yoon, 
• Sungsu Jung, 
• Eun Lee, 
• Song-I Yang & 
• Soo-Jong Hong 

BMC Pulmonary Medicine volume 19, Article number: 261 (2019)

Abstract

Background

Use of humidifier disinfectants (HD) at home leads to chemical airborne exposure, causing HD associated lung injury (HDLI) with high mortality. However, the lung function in children diagnosed with HDLI is not well studied. We investigated the effect of HD exposure on lung function, prognosis, and exposure characteristics associated with the lung function phenotype in children.

House dust mite sensitisation and association with atopic dermatitis in Brunei

• Research letter
• Open Access
• Clinical and Translational Allergy

• Haziq Emran, 
• Christina Siew Eng Chieng, 
• Surita Taib & 
• Anne Catherine Cunningham 

Clinical and Translational Allergy volume 9, Article number: 65 (2019) 

• details

Abstract

IgE sensitisation in tropical areas is under-reported. A 2 year retrospective cohort study of allergy data specific to aero and food allergens in Brunei demonstrated that specific IgE levels to house dust mite (Dermatophagoides pteronyssinus, D.farinae, Blomia tropicalis) were highest in this population and correlated with atopic dermatitis (p < 0.001). Shrimp and peanut were the most common food allergens. A dominance of house/storage mite sensitization is seen in Brunei which is consistent with other tropical countries.

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10 TOP PAPERS FOR 2019—ALLERGY AND CLINICAL IMMUNOLOGY

#1

REVIEW

Emerging Therapies in Chronic Spontaneous Urticaria.

Taek Ki Min, Sarbjit S Saini

Chronic spontaneous urticaria (CSU) is characterized by typically short-lived and fleeting wheals, angioedema or both, which occur spontaneously and persist for longer than 6 weeks. This term is applied to the most common subtype of chronic urticaria. The underlying pathophysiology for CSU involves mast cell and basophil degranulation with release of histamine, leukotrienes, prostaglandins and other inflammatory mediators. Although a variety of treatments exist, many patients do not tolerate or benefit from the existing therapies and even require more effective treatments...

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July 2019: Allergy, Asthma & Immunology Research

#2

REVIEW

How I investigate Eosinophilia.

Rebecca L Larsen, Natasha M Savage

Eosinophilia is typically secondary, that is, reactive, in nature and is associated with a wide variety of neoplastic and non-neoplastic disorders. Clonal eosinophilia is also seen in a wide variety of hematopoietic neoplasms, and sub-classification can be diagnostically challenging. A proper evaluation of persistent eosinophilia involves correlation of clinical history, laboratory data, cellular morphology, and ancillary testing. Knowledge of appropriate ancillary testing is necessary for a timely diagnosis...

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