Perspectives in allergen immunotherapy: 2019 and beyond

First published: 24 December 2019 https://doi.org/10.1111/all.14077

REVIEW ARTICLE - Open Access

Oliver Pfaar  Ioana Agache  Frédéric de Blay  Sergio Bonini  Adam M. Chaker  Stephen R. Durham  Radoslaw Gawlik  Peter W. Hellings  Marek Jutel  Jörg Kleine‐Tebbe  Ludger Klimek  Matthias V. Kopp  Andreas Nandy  Ronald L. Rabin  Ronald van Ree  Harald Renz  Graham Roberts  Anne‐Marie Salapatek  Carsten B. Schmidt‐Weber  Mohamed H. Shamji  Gunter J. Sturm  J. Christian Virchow  Ulrich Wahn  Christoph Willers  Petra Zieglmayer  Cezmi A. Akdis

Abstract

The seventh “Future of the Allergists and Specific Immunotherapy (FASIT)” workshop held in 2019 provided a platform for global experts from academia, allergy clinics, regulatory authorities and industry to review current developments in the field of allergen immunotherapy (AIT). Key domains of the meeting included the following:

Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper

• Review
• Open Access
• Clinical and Translational Allergy

• Valerie Hox, 
• Evelijn Lourijsen, 
• […]
• Philippe Gevaert 

Clinical and Translational Allergy volume 10, Article number: 1 (2020) 

Abstract

Because of the inflammatory mechanisms of most chronic upper airway diseases such as rhinitis and chronic rhinosinusitis, systemic steroids have been used for their treatment for decades. However, it has been very well documented that—potentially severe—side-effects can occur with the accumulation of systemic steroid courses over the years. A consensus document summarizing the benefits of systemic steroids for each upper airway disease type, as well as highlighting the potential harms of this treatment is currently lacking.

Efficacy and Safety of Multiple Dupilumab Dose Regimens After Initial Successful Treatment in Patients With Atopic Dermatitis A Randomized Clinical Trial

Original Investigation

Margitta Worm, MD¹; Eric L. Simpson, MD²; Diamant Thaçi, MD³; et alRobert Bissonnette, MD⁴; Jean-Philippe Lacour, MD⁵; Stefan Beissert, MD⁶; Makoto Kawashima, MD⁷; Carlos Ferrándiz, MD, PhD⁸; Catherine H. Smith, MD⁹; Lisa A. Beck, MD¹⁰; Kuo-Chen Chan, PhD¹¹; Zhen Chen, PhD¹¹; Bolanle Akinlade, MD¹¹; Thomas Hultsch, MD¹²; Heribert Staudinger, MD, PhD¹³; Abhijit Gadkari, PhD¹¹; Laurent Eckert, PhD¹⁴; John D. Davis, PhD¹¹; Manoj Rajadhyaksha, PhD¹¹; Neil M. H. Graham, MB, BS, MD, MPH¹¹; Gianluca Pirozzi, MD, PhD¹³; Neil Stahl, PhD¹¹; George D. Yancopoulos, MD, PhD¹¹; Marius Ardeleanu, MD¹¹

Author Affiliations Article Information

JAMA Dermatol. doi:https://doi.org/10.1001/jamadermatol.2019.3617

Key Points

Question  Do dupilumab regimens less frequent than once weekly or every 2 weeks maintain long-term efficacy and safety?

Findings  In this randomized clinical trial of 422 patients, high-responding patients previously treated for 16 weeks with 300 mg of dupilumab weekly or every 2 weeks who continued those regimens had the most consistent efficacy; patients taking lower-dose regimens (every 4 or 8 weeks) or placebo had a dose-dependent reduction in response and no safety advantage.

Expression of COX-1, COX-2, 5-LOX and CysLT2CysLT2 in nasal polyps and bronchial tissue of patients with aspirin exacerbated airway disease

• Research
• Open Access

Allergy, Asthma & Clinical Immunology

• Monique Vorsprach, 
• Christoph Arens, 
• Stephan Knipping, 
• Dörte Jechorek, 
• Sabine Stegemann-Koniszewski, 
• Eva Lücke & 
• Jens Schreiber 

Allergy, Asthma & Clinical Immunology volume 15, Article number: 83 (2019) 

• details

Abstract

Background

Aspirin exacerbated respiratory disease (AERD) is a disease of the upper and lower airways. It is characterized by severe asthma, chronic sinusitis with nasal polyps (CRSwNP) and intolerance towards nonsteroidal analgesics (NSAR). Arachidonic acid (AA) metabolites play an important role in the pathogenesis of AERD. It is still unknown, whether metabolism of AA is comparable between the upper and lower airways as well as between patients with and without NSAR intolerance.

Early-life exposure to humidifier disinfectant determines the prognosis of lung function in children

• Research article
• Open Access
• Open Peer Review

BMC Pulmonary Medicine

• Hyun-Ju Cho, 
• So Yeon Lee, 
• Donguk Park, 
• Seung-Hun Ryu, 
• Jisun Yoon, 
• Sungsu Jung, 
• Eun Lee, 
• Song-I Yang & 
• Soo-Jong Hong 

BMC Pulmonary Medicine volume 19, Article number: 261 (2019)

Abstract

Background

Use of humidifier disinfectants (HD) at home leads to chemical airborne exposure, causing HD associated lung injury (HDLI) with high mortality. However, the lung function in children diagnosed with HDLI is not well studied. We investigated the effect of HD exposure on lung function, prognosis, and exposure characteristics associated with the lung function phenotype in children.

House dust mite sensitisation and association with atopic dermatitis in Brunei

• Research letter
• Open Access
• Clinical and Translational Allergy

• Haziq Emran, 
• Christina Siew Eng Chieng, 
• Surita Taib & 
• Anne Catherine Cunningham 

Clinical and Translational Allergy volume 9, Article number: 65 (2019) 

• details

Abstract

IgE sensitisation in tropical areas is under-reported. A 2 year retrospective cohort study of allergy data specific to aero and food allergens in Brunei demonstrated that specific IgE levels to house dust mite (Dermatophagoides pteronyssinus, D.farinae, Blomia tropicalis) were highest in this population and correlated with atopic dermatitis (p < 0.001). Shrimp and peanut were the most common food allergens. A dominance of house/storage mite sensitization is seen in Brunei which is consistent with other tropical countries.

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