Maternal fish oil and/or probiotics intervention: Allergic diseases in children up to two years old

Komulainen, M, Saros, L, Vahlberg, T, Nermes, M, Jartti, T, Laitinen, K.  Pediatr Allergy Immunol. 2023; 34:e14004. doi:10.1111/pai.14004

Abstract

Background

As n-3 long-chain polyunsaturated fatty acids and probiotics possess immunomodulatory properties, theoretically they could lower the risk of allergic diseases. But their effects remain controversial. We aimed to study the effects of fish oil and probiotics separately or in combination from early pregnancy onwards to lower the risk of allergic diseases in the infants.

Methods

In this double-blind trial, women (n = 439) in early pregnancies were randomized into four intervention groups: fish oil + placebo, probiotics + placebo, fish oil + probiotics, and placebo + placebo.

Effect of monitoring adherence to regular inhaled corticosteroid (ICS) alone or in combination with a long-acting β2-agonist (LABA) using electronic methods on asthma outcomes: a narrative systematic review

Almutairi M, Marriott JF, Mansur A. BMJ Open. 2023 Aug 16;13(8):e074127. doi: 10.1136/bmjopen-2023-074127. 

Abstract

Objectives: To evaluate through a systematic review the effectiveness of electronic methods in monitoring adherence to regular inhaled corticosteroids (ICS) alone or in combination with long-acting β2-agonists (LABAs) and their effect on clinical outcomes.

Design: A narrative systematic review.

Data sources: MEDLINE, EMBASE, Cochrane Database of Systematic Reviews and Web of Science were searched through up to 10 July 2022.

Eligibility criteria: We included peer-reviewed studies of qualitative and quantitative outcomes that compared the effect of electronic methods to routine non-electronic monitoring intervention or placebo among children and adults with asthma on medication adherence rates to regular ICS alone or in combination with LABA, asthma control and asthma exacerbations.

Oral and nasal provocation test in chicken egg allergy—case report

• Case report
• Open Access
• 
  

• E. Krzych-Fałta, 
• O. Wojas, 
• P. Samel-Kowalik, 
• B. Samoliński, 
• A. Sybilski & 
• S. Białek 

Allergy, Asthma & Clinical Immunology volume 19, Article number: 70 (2023) 

• details

Abstract

Introduction

Allergy to chicken egg protein is a common form of food allergy. The most common clinical presentation includes gastrointestinal, skin, and respiratory symptoms. Differential diagnosis, including provocative tests, is critical in diagnosis.

Case description

We present a case of a 21-year-old patient with egg allergy, who underwent a double-blind food provocation test with placebo (evaluating subjective complaints from the gastrointestinal tract) and a titrated nasal provocation test using dry chicken egg content. We assessed the response of the nasal mucosa in the provocation test using the visual analogue scale (VAS), acoustic and optical rhinometry, as well as measurements of nitric oxide concentration in the exhaled air. During the provocation test, we measured the changes in the transverse section of the nasal passages, which were accompanied by subjective complaints measured with the VAS scale, using objective techniques. In the nasal provocation test with a dose of 20 µg of chicken egg protein, we observed an increase in the reactivity of the nasal mucosa and a decrease in the level of nitric oxide in the exhaled air from the upper airways (920 ppb before the provocation test and up to 867 ppb during the early stage of the allergic reaction). During the provocation tests, we recorded typical symptoms associated with the early stage of the allergic reaction; including nasal obstruction (1.2 cm), leakage of watery discharge (0.8 cm) in the food test, and itchy nose (1.1 cm) in the food test vs. the nasal test: 4.6, 2.8, and 3.5 cm, respectively.

Conclusions

The nasal mucosa provides convenient conditions for evaluation of the severity of allergy to common food allergens, including chicken egg allergens.

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Management of Mechanical Nasal Obstruction Isolated or Associated to Upper Airway Inflammatory Diseases in Real Life: Use of both Subjective and Objective Criteria

Merma-Linares, C., Martinez, M.D., Gonzalez, M. et al. Curr Allergy Asthma Rep (2023). https://doi.org/10.1007/s11882-023-01104-y

Abstract

Purpose of Review

Objective criteria score of mechanical nasal obstruction (0–6). 
a Nasal septum score (0–2): 0 = “no septum deformity”;
1 = “non obstructive septum deformity”;
2 = “obstructive septum deformity”. 
b Inferior turbinate score (0–4):0 = “no inferior turbinate enlargement”;
1 = “non obstructive turbinate enlargement;
2 = “obstructive turbinate enlargement

Mechanical nasal obstruction (MNO) is a prevalent condition with a high impact on patient’s quality-of-life (QoL) and socio-economic burden. The aim of this study was to determine the usefulness of both subjective and objective criteria in the appropriate management of MNO, either alone or associated to upper airway inflammatory diseases such as allergic rhinitis (AR) or chronic rhinosinusitis with nasal polyps (CRSwNP).

Recent Findings

A long debate persists about the usefulness of subjective and objective methods for making decisions on the management of patients with nasal obstruction. Establishing standards and ranges of symptom scales and questionnaires is essential to measure the success of an intervention and its impact on QoL. To our knowledge this is the first real-life study to describe the management of MNO using both subjective and objective criteria in MNO isolated or associated to upper airway inflammatory diseases (AR or CRSwNP).

Distinction between rhinitis alone and rhinitis with asthma using interactomics

Aguilar, D., Lemonnier, N., Melén, E. et al. Sci Rep 13, 13125 (2023). https://doi.org/10.1038/s41598-023-39987-6

Abstract

Interactomes of rhinitis alone and rhinitis associated with 

multimorbidity. DEGs: differentially expressed genes. 

For clarity, only genes with HGNC symbol are shown.

The concept of “one-airway-one-disease”, coined over 20 years ago, may be an over-simplification of the links between allergic diseases. Genomic studies suggest that rhinitis alone and rhinitis with asthma are operated by distinct pathways. In this MeDALL (Mechanisms of the Development of Allergy) study, we leveraged the information of the human interactome to distinguish the molecular mechanisms associated with two phenotypes of allergic rhinitis: rhinitis alone and rhinitis in multimorbidity with asthma. We observed significant differences in the topology of the interactomes and in the pathways associated to each phenotype. In rhinitis alone, identified pathways included cell cycle, cytokine signalling, developmental biology, immune system, metabolism of proteins and signal transduction. In rhinitis and asthma multimorbidity, most pathways were related to signal transduction. The remaining few were related to cytokine signalling, immune system or developmental biology. Toll-like receptors and IL-17-mediated signalling were identified in rhinitis alone, while IL-33 was identified in rhinitis in multimorbidity.

Dupilumab-induced eosinophilia in patients with diffuse type 2 chronic rhinosinusitis

Ryser FS, Yalamanoglu A, Valaperti A, Brühlmann C, Mauthe T, Traidl S, Soyka MB, Steiner UC. Allergy. 2023 Aug 7. doi: 10.1111/all.15844.

ORIGINAL ARTICLE Open Access

Abstract

Background

Dupilumab, a monoclonal anti-IL-4Rα antibody, is approved for several type 2 mediated inflammatory diseases like asthma, atopic dermatitis, and diffuse type 2 chronic rhinosinusitis (CRS). Clinical studies had reported a transient increase in blood eosinophils during dupilumab therapy.
This study aimed to assess the impact of elevated blood eosinophils on clinical outcome and to investigate the cause of high blood eosinophil levels under dupilumab therapy.

Methods

Patients suffering from diffuse type 2 CRS treated with dupilumab were examined on days 0, 28, 90, and 180 after therapy start. Sino-Nasal-Outcome-Test Score (SNOT-22), Total Nasal Polyp Score (TNPS), and blood samples were collected.

Identification of allergens in Artocarpus heterophyllus, Moringa oleifera, Trianthema portulacastrum and Syzygium samarangense

• Research
• Open Access
• 
  

• Janitha Iddagoda, 
• Peshala Gunasekara, 
• Shiroma Handunnetti, 
• Chandima Jeewandara, 
• Chandima Karunatilake, 
• Gathsaurie Neelika Malavige, 
• Rajiva de Silva & 
• Dhanushka Dasanayake 

Clinical and Molecular Allergy volume 21, Article number: 6 (2023) 

• details

Abstract

Background

It is clinically important to identify allergens in Artocarpus heterophyllus (jackfruit), Moringa oleifera (moringa), Trianthema portulacastrum (horse purslane) and Syzygium samarangense (rose apple). This study included 7 patients who developed anaphylaxis to jackfruit (1), moringa (2), horse purslane (3) and rose apple (1). We sought to determine allergens in the edible ripening stages of jackfruit (tender, mature, and ripened jackfruit) and seeds, edible parts of moringa (seeds, seedpod, flesh inside seedpod, and leaves), horse purslane leaves and ripened rose apple fruit. The persistence of the allergens after cooking was also investigated.

Methods

Allergens were identified by clinical history followed by a skin prick test. Protein profiles of plant/fruit crude protein extracts were determined by SDS-PAGE. Molecular weights of the allergens were determined by immunoblotting with patient sera.

Severity of SARS-CoV-2 infection in children with inborn errors of immunity (primary immunodeficiencies): a systematic review

• Research
• Open Access
• 
  

Alhumaid S, Al Mutared KM, Al Alawi Z, et al. Allergy Asthma Clin Immunol. 2023 Aug 9;19(1):69. 

• details

Abstract

Background

Inborn errors of immunity (IEIs) are considered significant challenges for children with IEIs, their families, and their medical providers. Infections are the most common complication of IEIs and children can acquire coronavirus disease 2019 (COVID-19) even when protective measures are taken.

Objectives

To estimate the incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children with IEIs and analyse the demographic parameters, clinical characteristics and treatment outcomes in children with IEIs with COVID-19 illness.

Methods

For this systematic review, we searched ProQuest, Medline, Embase, PubMed, CINAHL, Wiley online library, Scopus and Nature through the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) guideline for studies on the development of COVID-19 in children with IEIs, published from December 1, 2019 to February 28, 2023, with English language restriction.