Drug-Induced Angioedema Without Urticaria: A Case Report

Raikar S R, G S, Sneha S, et al. (July 13, 2024) Cureus 16(7): e64452. doi:10.7759/cureus.64452

Abstract

Diclofenac-induced hypersensitivity reaction - angioedema

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for various conditions but are associated with numerous adverse drug reactions (ADRs). Understanding these ADRs is necessary to reduce morbidity and mortality. NSAID-induced angioedema, although rare, can be life-threatening and is often due to increased leukotriene production from COX pathway inhibition.

Mast cells and basophil degranulation play vital roles in its pathogenesis. Prompt recognition and immediate cessation of the culprit drug, along with the administration of corticosteroids and antihistamines, are essential. Here, we report a case of angioedema caused by diclofenac administration, which needs prompt vigilance and a rapid therapeutic response.

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